2021 Hyperpolarized MRI Course
Course Details
Organizers & Instructors:
Peder Larson, PhD
Associate Professor
[email protected]
Jeremy Gordon, PhD
Assistant Professor
[email protected]
Renuka Sriram, PhD
Assistant Professor
[email protected]
Additional Lecturers:
Pavithra Viswanath, PhD
Associate Professor
[email protected]
Michael Ohliger, MD, PhD
Associate Professor, Abdominal & Liver Radiologist
[email protected]
Hsin-Yu Chen, PhD
Senior Bioengineer
[email protected]
Caroline Guglielmetti, PhD
Assistant Researcher
[email protected]
Celine Taglang, PhD
Postdoctoral Scholar
[email protected]
Yaewon Kim, PhD
Postdoctoral Scholar
[email protected]
Administrative Support:
Jenny Che
Program Officer
Contact for: Course Administrative Oversight
[email protected]
Jenna Bernard, PhD
Program Manager
Contact for: Course Website & Virtual Meetings
[email protected]
Cresini Tabaranza-David
Executive Analyst
Contact for In-person Room Support
[email protected]
Phone: (415) 514-4450
Course Description:
Hyperpolarized NMR and MRI is an emerging modality that can be used to study biochemical reactions, including metabolic conversion, as well as pH, redox potential, perfusion, transport, and more. It has promising clinical applications for cancer imaging, as well as potential for novel experiments in pre-clinical models and cells. This modality is enabled by the development of Dissolution Dynamic Nuclear Polarization (DNP), which requires specialized equipment to prepare a hyperpolarized solution for experiments. This course covers the mechanisms behind Dissolution DNP and experimental considerations. *The HP MRI Book titled "Hyperpolarized Carbon-13 Magnetic Resonance Imaging and Spectroscopy" Academic Press, Elsevier 2021 editor: Dr. Peder Larson is available for purchase online.
Course Materials
Lecture 1:
Air Date: June 21st 2021
Topic: Introduction and DNP Physics
Lecturers:
Renuka Sriram, PhD, Assistant Professor
& Jeremy Gordon, PhD, Assistant Professor
Hands-on Training:
Hypersense/SPINlab Operation
Meeting Recording & Slides:
Introduction to Hyperpolarized C-13 MR
Slides Recording (22 mins)
Hyperpolarized 13C MRI: Polarization Physics
Slides Recording (40 mins)
Reference Materials:
HP MRI Book* - Chapter 1 DNP Physics
HP MRI Book* - Chapter 2 DNP Hardware
HP MRI Book* - Chapter 3 Acquisition Methods
Lecture 2:
Air Date: June 29th 2021
Topic: DNP Hardware
Lecturer:
Yaewon Kim, PhD, Postdoctoral Scholar
Hands-on Training:
Hypersense/SPINlab Operation
Meeting Recording & Slides:
DNP Hardware
Slides Recording (51 mins)
Reference Materials:
HP MRI Book* - Chapter 1 DNP Physics
HP MRI Book* - Chapter 2 DNP Hardware
HP MRI Book* - Chapter 3 Acquisition Methods
Lecture 3:
Air Date: July 12th 2021
Topic: MR Acquisition
Lecturer:
Jeremy Gordon, PhD, Assistant Professor
Hands-on Training:
Hypersense/SPINlab Operation
Meeting Recording & Slides:
MR Acquisition
Slides Recording (1hr 8 min)
Reference Materials:
HP MRI Book* - Chapter 1 DNP Physics
HP MRI Book* - Chapter 2 DNP Hardware
HP MRI Book* - Chapter 3 Acquisition Methods
Review Articles:
Comparison of acquisition schemes for hyperpolarised ¹³C imaging
Hyperpolarized Metabolic MRI-Acquisition, Reconstruction, and Analysis Methods
Lecture 4:
Air Date: July 19th, 2021
Topic: Introduction and DNP Physics
Topic: DNP Agents
Lecturer:
Dr. Celine Taglang. PhD, Postdoctoral Scholar
Hands-on Training:
Sample Prep
Meeting Recording & Slides:
Slides Recording
Reference Materials:
HP MRI Book* - Chapter 6 Agents and Biochemical Interactions
Lecture 5:
Air Date: July 26th, 2021
Topic: Hyperpolarized MR Experimental Methods – Cells and Animals
Lecturer:
Renuka Sriram, PhD, Assistant Professor
Hands-on Training:
Mock Hyperpolarized Studies – cell/tissue, animal, human
Meeting Recording & Slides:
Slides Recording
Reference Materials:
HP MRI Book* - Chapter 4 Experimental Methods Preclinical
Lecture 6:
Air Date: August 2nd, 2021
Topic: Hyperpolarized MR Experimental Methods – Human
Lecturer:
Hsin-Yu Chen, PhD, Senior Bioengineer
Hands-on Training:
Mock Hyperpolarized Studies – cell/tissue, animal, human
Meeting Recording & Slides:
Slides Recording
Reference Materials:
N/A
Lecture 7:
Air Date: August 9th, 2021
Topic: Integration of Hyperpolarized MR Into Biomedical Research: Cancer
Lecturer:
Pavithra Viswanath, PhD, Associate Professor
Hands-on Training:
N/A
Meeting Slides:
Slides
Reference Materials:
HP MRI BOOK* - Chapter 8 Cancer
Lecture 8:
Air Date: August 16th, 2021
Topic: Integration of Hyperpolarized MR Into Biomedical Research: Neurological & Cardiac Disease
Lecturers:
Caroline Guglielmetti, PhD, Assistant Researcher
& Peder Larson, PhD, Associate Professor
Hands-on Training:
Clinical Fluid Paths Prep
Meeting Recording & Slides:
Applications of Hyperpolarized Carbon-13 MR: The Heart
Slides Recording
Integration of Hyperpolarized MR Into Biomedical Research: Neurological
Slides
Reference Materials:
HP MRI BOOK* - Chapter 9 Neurological
HP MRI BOOK* - Chapter 10 Cardiac
Lecture 9:
Air Date: August 23rd, 2021
Topic: Integration of Hyperpolarized MR Into Biomedical Research: Liver Disease
Lecturers:
Michael Ohliger, MD, PhD, Associate Professor, Abdominal & Liver Radiologist
Hands-on Training:
Interpretation Workflow Q&A
Meeting Recording & Slides:
Recording
Reference Materials:
HP MRI BOOK* - Chapter 11 Liver
Lecture 10:
Air Date: August 30th, 2021
Topic: Hyperpolarized Data Visualization and Analysis
Lecturers:
Peder Larson, PhD, Associate Professor
& Hsin-Yu Chen, PhD, Senior Bioengineer
Hands-on Training: Data Analysis
Meeting Recording & Slides:
Slides | Lecture Recording | Hands-on Recording
Reference Materials:
HP MRI BOOK* - Chapter 7 Analysis and Visualization
Live Demo Links:
My Binder - Demo Notebooks
My Binder - Exercises
GitHub - Exercises
Hands-on Training Resources:
Jupyter Notebook
*The HP MRI Book titled "Hyperpolarized Carbon-13 Magnetic Resonance Imaging and Spectroscopy" Academic Press, Elsevier 2021 editor: Dr. Peder Larson is available for purchase online.
2019 HP MRI Course - View Here
