2021 Hyperpolarized MRI Course
 

Course Details

Organizers & Instructors:


Peder Larson, PhD 
Associate Professor
[email protected]

Jeremy Gordon, PhD
Assistant Professor
[email protected]  

Renuka Sriram, PhD
Assistant Professor
[email protected]

Additional Lecturers:


Pavithra Viswanath, PhD
Associate Professor
[email protected]

Michael Ohliger, MD, PhD
Associate Professor, Abdominal & Liver Radiologist
[email protected]

Hsin-Yu Chen, PhD
Senior Bioengineer
[email protected]

Caroline Guglielmetti, PhD
Assistant Researcher
[email protected]

Celine Taglang, PhD
Postdoctoral Scholar
[email protected]

Yaewon Kim, PhD
Postdoctoral Scholar
[email protected]

Administrative Support:


Jenny Che
Program Officer
Contact for: Course Administrative Oversight
[email protected] 

Jenna Bernard, PhD
Program Manager
Contact for: Course Website & Virtual Meetings
[email protected]

Cresini Tabaranza-David
Executive Analyst
Contact for In-person Room Support
[email protected]
Phone: (415) 514-4450

Course Description: 

Hyperpolarized NMR and MRI is an emerging modality that can be used to study biochemical reactions, including metabolic conversion, as well as pH, redox potential, perfusion, transport, and more.  It has promising clinical applications for cancer imaging, as well as potential for novel experiments in pre-clinical models and cells.  This modality is enabled by the development of Dissolution Dynamic Nuclear Polarization (DNP), which requires specialized equipment to prepare a hyperpolarized solution for experiments.  This course covers the mechanisms behind Dissolution DNP and experimental considerations. *The HP MRI Book used in this course is available by request. Please email [email protected] to be added to the BOX folder. 


 

Course Materials

Lecture 1: 

Air Date: June 21st 2021

Topic: Introduction and DNP Physics

Lecturers: 
Renuka Sriram, PhD, Assistant Professor
Jeremy Gordon, PhD, Assistant Professor

Hands-on Training:
Hypersense/SPINlab Operation

Meeting Recording & Slides: 
​Introduction to Hyperpolarized C-13 MR
Slides Recording (22 mins)

Hyperpolarized 13C MRI: Polarization Physics
Slides Recording (40 mins)

Reference Materials:
HP MRI Book* - Chapter 1 DNP Physics
HP MRI Book* - Chapter 2 DNP Hardware
HP MRI Book* - Chapter 3 Acquisition Methods

Lecture 2: 

Air Date: June 29th 2021

Topic: DNP Hardware

Lecturer: 
Yaewon Kim, PhD, Postdoctoral Scholar

Hands-on Training:
Hypersense/SPINlab Operation

Meeting Recording & Slides: 
DNP Hardware
Slides Recording (51 mins)

Reference Materials:
HP MRI Book* - Chapter 1 DNP Physics
HP MRI Book* - Chapter 2 DNP Hardware
HP MRI Book* - Chapter 3 Acquisition Methods

Lecture 3: 

Air Date: July 12th 2021

Topic: MR Acquisition

Lecturer: 
Dr. Jeremy Gordon, PhD, Assistant Professor

Hands-on Training:
Hypersense/SPINlab Operation

Meeting Recording & Slides: 
MR Acquisition
Slides Recording (1hr 8 min)

Reference Materials:
HP MRI Book* - Chapter 1 DNP Physics
HP MRI Book* - Chapter 2 DNP Hardware
HP MRI Book* - Chapter 3 Acquisition Methods

Review Articles:
Comparison of acquisition schemes for hyperpolarised ¹³C imaging

Hyperpolarized Metabolic MRI-Acquisition, Reconstruction, and Analysis Methods

Lecture 4: 

Air Date: July 19th, 2021

Topic: Introduction and DNP Physics

Topic: DNP Agents

Lecturer: 
Dr. Celine Taglang. PhD, Postdoctoral Scholar

Hands-on Training:
Sample Prep

Meeting Recording & Slides: 
Slides Recording

Reference Materials:
HP MRI Book* - Chapter 6 Agents and Biochemical Interactions

Lecture 5: 

Air Date: July 26th, 2021

Topic: Hyperpolarized MR Experimental Methods – Cells and Animals

Lecturer: 
Renuka Sriram, PhD, Assistant Professor

Hands-on Training:
Mock Hyperpolarized Studies – cell/tissue, animal, human

Meeting Recording & Slides: 
Slides Recording

Reference Materials:
HP MRI Book* - Chapter 4 Experimental Methods Preclinical

Lecture 6: 

Air Date: August 2nd, 2021

Topic: Hyperpolarized MR Experimental Methods – Human

Lecturer: 
Hsin-Yu Chen, PhD, Senior Bioengineer

Hands-on Training:
Mock Hyperpolarized Studies – cell/tissue, animal, human

Meeting Recording & Slides: 
Slides Recording

Reference Materials:
N/A

Lecture 7: 

Air Date: August 9th, 2021

Topic:  Integration of Hyperpolarized MR Into Biomedical Research: Cancer

Lecturer: 
Pavithra Viswanath, PhD, Associate Professor

Hands-on Training:
N/A

Meeting Slides: 
Slides

Reference Materials:
HP MRI BOOK* - Chapter 8 Cancer 

 

Lecture 8: 

Air Date: August 16th, 2021

Topic: Integration of Hyperpolarized MR Into Biomedical Research: Neurological & Cardiac Disease

Lecturers: 
Caroline Guglielmetti, PhD, Assistant Researcher
Peder Larson, PhD, Associate Professor

Hands-on Training:
Clinical Fluid Paths Prep

Meeting Recording & Slides: 
Applications of Hyperpolarized Carbon-13 MR: The Heart 
Slides Recording

Integration of Hyperpolarized MR Into Biomedical Research: Neurological
Slides

Reference Materials:
HP MRI BOOK* - Chapter 9 Neurological
HP MRI BOOK* - Chapter 10 Cardiac

Lecture 9: 

Air Date: August 23rd, 2021

Topic: Integration of Hyperpolarized MR Into Biomedical Research: Liver Disease

Lecturers: 
Michael Ohliger, MD, PhD, Associate Professor, Abdominal & Liver Radiologist

Hands-on Training: 
Interpretation Workflow Q&A

Meeting Recording & Slides: 
Recording

Reference Materials:
HP MRI BOOK* - Chapter 11 Liver

Lecture 10: 

Air Date: August 30th, 2021

Topic: Hyperpolarized Data Visualization and Analysis

Lecturers: 
Peder Larson, PhD, Associate Professor
Hsin-Yu Chen, PhD, Senior Bioengineer

Hands-on Training: Data Analysis

Meeting Recording & Slides: 
Slides | Lecture Recording | Hands-on Recording

Reference Materials:
HP MRI BOOK* - Chapter 7 Analysis and Visualization

Live Demo Links:
My Binder - Demo Notebooks
My Binder - Exercises
GitHub - Exercises 

Hands-on Training Resources:
Jupyter Notebook

*The HP MRI Book is available by request. Please email [email protected] to be added to the BOX folder.

2019 HP MRI Course - View Here