The Hyperpolarized MRI Technology Resource Center
The Hyperpolarized MRI Technology Resource Center (HMTRC) is a Biomedical Resource Technology Center funded by the National Institute of Biomedical Imaging and Bioengineering (NIBIB) focuses on the development and dissemination of new advances in dissolution DNP techniques and instrumentation, specialized data acquisition methodology, and analysis software for biomedical research.
Hyperpolarized MR is an emerging molecular imaging method to monitor enzymatic conversions through key, previously-inaccessible biochemical pathways. Through numerous studies to date, hyperpolarized carbon-13 MR has shown outstanding research and potential clinical value, but requires major technological development to realize its full potential. This motivation, coupled with the rapidly expanding interest at other sites, compelled us to create the “Hyperpolarized MRI Technology Resource Center”.
This center is based on three Technology Research & Development (TR&D) projects led by experienced hyperpolarized MR researchers. TR&D1 is focused on DNP polarizer and MR acquisition development and pre-clinical animal studies. TR&D2 focuses on the development of new robust and realistic pre-clinical models for HP MR studies, optimization of current HP probes & investigation of new HP probes, and the development of methods that provide appropriate correlative pathologic, biologic and other imaging data for understanding and validating HP MR findings. TR&D3 focuses on the development of a free open-source specialized data analysis platform for HP MR data reconstruction and interpretation. All TR&D developments are driven in a push-pull interaction by the independently funded Collaborative Projects and the technology resources of the center are utilized by Service Projects and disseminated to all interested investigators through hands-on workshops, symposia, visits/training, formal courses, and our center website.
The goal of the HMTRC is to collaboratively develop new technology to advance this field in order to better identify and understand human disease and ultimately to translate and disseminate these techniques for improved healthcare.
Center HP C-13 MRI Technology Advances & Clinical Translation
Translation of Hyperpolarized MR
Into Biomedical Research (by Body Area)
Select a button below to view presentations on translation of Hyperpolarized MR into Biomedical Research by Body Area.
Bone | Brain | Breast | Cardiac | Head & Neck
Kidney | Liver | Neurology | Pancreas | Prostate | Thyroid
Bone
03/18/21
Hsin-Yu Chen, PhD, Senior Bioengineer, UCSF
International SPINlab Web-conference
Specialized Technology Developments for HP 13C-pyruvate MRI of Bone and Liver Metastases
(21 min)
Back to Clinical Translation (by Body Area)
Brain
11/21/23
Yaewon Kim, PhD, Postdoctoral Scholar Vigneron Group, UCSF
International HP C-13 MRI Seminar
Clinical HP 13C MR Molecular Imaging of Brain Metabolism: Probes beyond [1-13C]Pyruvate
(23 min)
Focus Area/s: Probes, Clinical Translation, Human, Metabolism, New HP Probe Development, Technology, Brain, Data Analysis
11/21/23
Mathilde Hauge Lerche, PhD, Associate Professor, Technical University of Denmark
International HP C-13 MRI Seminar
Converging new HP Methods, Large Animal Models and Biomarkers relevant for Clinical MR
(25 min)
Focus Area/s: Models, Preclinical, Metabolism, Clinical translation, Brain
10/24/23
Pavithra Viswanath, PhD, Associate Professor, UCSF
International HP C-13 MRI Seminar
Interrogating Glioma Biology using Hyperpolarized 13C MR Imaging
(22 min)
Focus Area/s: Preclinical, Brain, Cancer, New Agents
09/28/23
Jasmine Hu, PhD, Postdoctoral Scholar Vigneron Lab, UCSF
International HP C-13 MRI Seminar
Multi-Resolution HP [1-13C]Pyruvate MRI for Brain Metabolism & Perfusion
(18 min)
Focus Area/s: Acquisition, Data Analysis, Metabolic Imaging, Metabolism, Clinical Translation, Human, Brain
08/23/23
Adam Autry, PhD, Specialist, UCSF
HP MRI Course 2023
Clinical Translation of HP C-13 Imaging for Patients with Glioma
(32 min)
Focus Area/s: Clinical Translation - Brain Cancer & Patients
04/13/23
Chuck Cunningham PhD, University of Toronto
HMTRC Workshop 2023
Hyperpolarized C-13 MRI of the Human Brain
(20 min)
Focus Area/s: Clinical Translation, Human, Brain
04/14/23
Yan Li MD PhD, UCSF
HMTRC Workshop 2023
Imaging Tumor Metabolism for Improved Management of Patients with Glioma
(18 min)
Focus Area/s: Clinical Translation, Brain, Cancer
04/14/23
Pavithra Viswanath PhD, UCSF
HMTRC Workshop 2023
Probing the pentose phosphate pathway in brain tumors using hyperpolarized C-13 imaging
(14 min)
Focus Area/s: Preclinical, Brain Tumors
12/01/22
Yan Li, PhD, Assistant Professor, UCSF
International HP C-13 MRI Seminar
Dynamic Hyperpolarized 13C MRI of Pyruvate Metabolism in Patients with Glioma
(23 min)
Focus Area/s: Cancer, Clinical Translation, Brain, Metabolism
09/15/22
Jasmine Hu Graduate Student Vigneron Lab, UCSF
Multi-site Collaboration Presentation
Kinetic Analysis of Multi-resolution Hyperpolarized 13C Human Brain MRI to Study Cerebral Metabolism
(8 min)
Focus Area/s: Clinical Translation, Brain, Metabolism
08/16/22
Adam Autry, PhD, Research Specialist, UCSF
International HP C-13 MRI Seminar
Clinical Translation of Hyperpolarized Carbon-13 Imaging in Patients with Glioma
(17 min)
Focus Area/s: Cancer, Clinical Translation, Brain, Metabolism
06/22/22
Ferdia Gallagher, MD, PhD, Professor, University of Cambridge
HMTRC Radiology & Biomedical Imaging Hosted Seminar
Imaging Metabolism and Metabolic Heterogeneity in Oncology
(38 min)
Focus Area/s: Cancer, Clinical Translation - Treatment Response, Brain Metabolism, DMI
03/17/22
Susan Chang, MD, Professor, Neurological Surgery, UCSF Weill Institute for Neurosciences, UCSF
HMTRC Workshop 2022
Metabolic Imaging in Glioma
(31 min)
Focus Area/s: Clinical Translation, Brain
2/17/22
Charles Cunningham, PhD, Professor, University of Toronto & Senior Scientist at the Sunnybrook Research Institute
International HP C-13 MRI Seminar
Hyperpolarized 13C MRI of the Human Brain
(28 min)
Focus Area/s: Clinical Translation, Brain Cancer
04/01/21
Yaewon Kim, PhD, Postdoctoral Scholar, Vigneron Lab, UCSF
International SPINlab Web-conference
Focus Area/s: Data Analysis - Human, Clinical Translation - Brain
02/23/21
Javier Villanueva-Meyer, MD, Assistant Professor of Clinical Radiology in Neuroradiology, UCSF
International HP C-13 MRI Seminar
Hyperpolarized Carbon-13 Studies in Brain Tumors at UCSF
(24 min)
01/21/21
Adam Autry, PhD, Postdoctoral Scholar, Multimodal Metabolic Brain Imaging Lab, UCSF
Multi-site Collaboration Presentation
Recent Developments in HP C-13 Imaging of Pediatric to Adult Glioma
(15 min)
Focus Area/s: Clinical Translation - Brain Cancer
08/16/19
Adam Autry, PhD, Postdoctoral Scholar, Multimodal Metabolic Brain Imaging Lab, UCSF
HP MRI Course 2019
Using EPI to Investigate HP [1-13C]pyruvate Metabolism in Glioma Patients and Healthy Volunteers
(Slides)
Focus Area/s: Clinical Translation - Brain Cancer & Patients
Back to Clinical Translation (by Body Area)
Breast
12/07/21
Ramona Woitek, PhD
Senior Research Associate and Honorary Consultant Radiologist, University of
Cambridge
International HP C-13 MRI Seminar
Back to Clinical Translation (by Body Area)
Cardiac
08/09/23
Peder Larson, PhD, Professor, UCSF
HP MRI Course 2023
Integration of Hyperpolarized MR Into Biomedical Research: Cardiac Disease
(51 min)
Focus Area/s: Clinical Translation, Cardiac, Data Analysis
04/13/23
Chris Laustsen PhD, Aarhus University
HMTRC Workshop 2023
Is there a place for cardiac hyperpolarized [1-13C]pyruvate in the clinical toolbox?
(12 min)
Focus Area/s: Clinical Translation, Human, Cardiac
04/14/23
Vlad Zaha MD PhD, University of Texas Southwestern
HMTRC Workshop 2023
Lessons from Using Hyperpolarized C-13 labeled Substrates in Cardio-Oncology
(17 min)
Focus Area/s: Cardiac, Cancer
06/21/22
Peder Larson, PhD, Associate Professor, UCSF
International HP C-13 MRI Seminar
Quantification of Whole-heart Hyperpolarized 13C-pyruvate MRI
(25 min)
Focus Area/s: Clinical Translation, Cardiac, Data Analysis, Data & File Sharing
03/17/22
Charlie Khemtong, PhD, University of Florida
HMTRC Workshop 2022
Evaluation of Cellular Redox in Perfused Hearts with HP 13C MR
(18 min)
Focus Area/s: Cardiac, Probes
03/17/22
Craig Malloy, MD, Professor, UT Southwestern Medical Center
HMTRC Workshop 2022
Progress in Detection of PDH and the TCA cycle by 13C NMR
(25 min)
Focus Area/s: Cardiac, Clinical Translation
08/16/21
Peder Larson, PhD, Associate Professor, UCSF
HP MRI Course 2021
Applications of Hyperpolarized Carbon-13 MR: The Heart
(24 min)
Focus Area/s: Clinical Translation, Cardiac, Data Analysis
02/23/21
Craig Malloy, MD, Professor, UT Southwestern Medical Center
International HP C-13 MRI Seminar
Hyperpolarized MRI Research at UT Southwestern
(26 min)
Focus Area/s: Clinical Translation - Cardiac
03/05/20
Craig Malloy MD, Professor, UT Southwestern
HMTRC Workshop 2020
Human Imaging, HP 13C Imaging of the Heart & Software of Isotopomer Analysis
(19 min)
Focus Area/s: Clinical Translation - Cardiac
Data Analysis
08/09/19
Peder Larson, PhD, Associate Professor, UCSF
HP MRI Course 2019
Back to Clinical Translation (by Body Area)
Head & Neck
04/14/23
Stephen Lai MD PhD, UT MD Anderson Cancer Center
HMTRC Workshop 2023
Back to Clinical Translation (by Body Area)
Kidney
04/13/23
Zhen Jane Wang, MD, Medical Director, Professor, Abdominal Radiologist, UCSF
HMTRC Workshop 2023
Hyperpolarized C-13 MRI Clinical Translation Update
(22 min)
Focus Area/s: Clinical Translation, Kidney, Clinical Trials
04/14/23
Dan Crooks MS, PhD, NIH/NCI
HMTRC Workshop 2023
Metabolic and Mitochondrial Heterogeneity in Fumarate Hydratase-Deficient Renal Tumors
(15 min)
Focus Area/s: Cancer, Kidney, Metabolism
10/01/20
Zhen Jane Wang, MD, Medical Director, Professor, Abdominal Radiologist, UCSF
International SPINlab Web-conference
Initial Experience of Hyperpolarized 13C MRI in Patients with Renal Cell Carcinoma
(Slides)
Focus Area/s: Clinical Translation - Kidney
03/05/20
Zhen Jane Wang, MD, Medical Director, Professor, Abdominal Radiologist, UCSF
HMTRC Workshop 2020
HP 13C MRI of Renal Tumors - From Cells to Patients
(40 min)
Back to Clinical Translation (by Body Area)
Liver
10/03/23
Michael Ohliger, MD, PhD, Associate Professor, Abdominal & Liver Radiologist, UCSF
Advances in Artificial Intelligence & Novel Imaging Methods Conference
Integrating C-13 in Prostate and Liver Studies
(18 min)
Focus Area/s: Human, Metabolic Imaging, Metabolism, Liver, Prostate, Cancer
03/17/22
Michael Ohliger, MD, PhD, Associate Professor, Abdominal & Liver Radiologist, UCSF
HMTRC Workshop 2022
Hyperpolarized 13C in the Liver
(18 min)
Focus Area/s: Liver, Clinical Translation
03/17/22
Matthew Merritt, PhD, Associate Professor, University of Florida
HMTRC Workshop 2022
Detecting Real-Time Hepatic Ketogenesis with HP [2-13C]Pyruvate
(18 min)
Focus Area/s: Preclinical Probes - Liver
08/23/21
Michael Ohliger, MD, PhD, Associate Professor, Abdominal & Liver Radiologist, UCSF
HP MRI Course 2021
Integration of Hyperpolarized MR Into Biomedical Research: Liver Disease
(52 min)
Focus Area/s: Clinical Translation, Liver, Radiologist Interpretation
07/08/21
Philip Lee, Graduate Student, UCSF
International SPINlab Web-conference
Focus Area/s: Data Analysis - Human, Clinical Translation - Liver Cancer
04/22/21
Michael Ohliger, MD, PhD, Associate Professor, Abdominal & Liver Radiologist, UCSF
International HP C-13 MRI Seminar
Hyperpolarized Carbon-13 in Diffuse Liver Disease
(21 min)
Focus Area/s: Clinical Translation - Liver
03/18/21
Hsin-Yu Chen, PhD, Senior Bioengineer, UCSF
International SPINlab Web-conference
Specialized Technology Developments for HP 13C-pyruvate MRI of Bone and Liver Metastases
(21 min)
Focus Area/s: Clinical Translation - Bone & Liver Cancer
01/28/21
Matthew Merritt PhD, Associate Professor, University of Florida
International HP C-13 MRI Seminar
Hyperpolarized Dihydroxyacetone is a Sensitive Detector of Hepatic Glucose Metabolism
(33 min)
Focus Area/s: Preclinical Probes - Liver
03/05/20
Michael Ohliger, MD, PhD, Associate Professor, Abdominal & Liver Radiologist, UCSF
HMTRC Workshop 2020
HP 13C of the Liver: Promises and Challenges
(18 min)
Focus Area/s: Clinical Translation - Liver
08/09/19
Michael Ohliger, MD, PhD, Associate Professor, Abdominal & Liver Radiologist, UCSF
HP MRI Course 2019
Hyperpolarized 13C MRI in the Liver: Microscope for in vivo Metabolism
(26 min)
Back to Clinical Translation (by Body Area)
Neurology
08/09/23
Myriam Chaumeil, PhD, Associate Professor, UCSF
HP MRI Course 2023
Integration of Hyperpolarized MR Into Biomedical Research: Neurological
(Slides)
Focus Area/s: Preclinical Models
04/14/23
Myriam Chaumeil PhD, UCSF
HMTRC Workshop 2023
Recent advances in preclinical HP C-13 metabolic neuroimaging
(14 min)
Focus Area/s: Preclinical, Neurology
03/17/22
Christoffer Laustsen, PhD, Professor and Research Director, Aarhus University
HMTRC Workshop 2022
New Neuro Applications in Aarhus - Future Considerations
(22 min)
Focus Area/s: Clinical Translation, Neurology
08/16/21
Caroline Guglielmetti, PhD, Assistant Researcher, UCSF
HP MRI Course 2021
Integration of Hyperpolarized MR Into Biomedical Research: Neurological
(Slides)
08/23/19
Lydia Le Page, PhD, Postdoctoral Scholar, Chaumeil Lab, UCSF
HP MRI Course 2019
Integration of Hyperpolarized MR into Biomedical Research: Neurological
(Slides)
Focus Area/s: Clinical Translation - Neurology
Back to Clinical Translation (by Body Area)
Pancreas
04/14/23
Matthew Merritt PhD, University of Florida
HMTRC Workshop 2023
Investigating Pancreas Metabolism with Hyperpolarized [1-13C]Pyruvate
(14 min)
06/09/21
Jeremy Gordon, PhD, Assistant Professor, UCSF
International SPINlab Web-conference
Hyperpolarized 13C Metabolic Imaging of Patients with Pancreatic Ductal Adenocarcinoma
(9 min)
Focus Area/s: Clinical Translation - Pancreas Cancer
Back to Clinical Translation (by Body Area)
Prostate
10/03/23
Michael Ohliger, MD, PhD, Associate Professor, Abdominal & Liver Radiologist, UCSF
Advances in Artificial Intelligence & Novel Imaging Methods Conference
Integrating C-13 in Prostate and Liver Studies
(18 min)
Focus Area/s: Human, Metabolic Imaging, Metabolism, Liver, Prostate, Cancer
04/13/23
Robert Bok MD PhD, UCSF
HMTRC Workshop 2023
Update of Hyperpolarized C-13 MRI for Active Surveillance
in Prostate Cancer Subjects
(14 min)
Focus Area/s: Clinical Translation, Human, Prostate
04/14/23
Ivan De Kouchkovsky MD & Rahul Aggarwal MD, UCSF
HMTRC Workshop 2023
Emerging Clinical Applications of Hyperpolarized C-13 MRI in Prostate Cancer
(17 min)
Focus Area/s: Clinical Translation, Human, Prostate Cancer
04/14/23
Adam Retter MD PhD Candidate, University College London
HMTRC Workshop 2023
C-13 Pyruvate Hyperpolarised MR in patients with prostate cancer on active surveillance
(14 min)
Focus Area/s: Clinical Translation, Prostate Cancer
04/14/23
Hsin-Yu Chen PhD, UCSF
HMTRC Workshop 2023
Focus Area/s: Clinical Translation, Prostate Cancer, Acquisition Methods
09/27/22
Hsin-Yu Chen, PhD
Senior Bioengineer, UCSF
International HP C-13 MRI Seminar
Focus Area/s: Prostate, Clinical Translation, Human, Data Analysis
08/16/22
Nikita Sushentsev, MD, PhD Student and Gates Scholar, University of Cambridge
International HP C-13 MRI Seminar
Hyperpolarised 13C-MRI for Targeting Glycolytic Tumour Core in Prostate Cancer
(11 min)
Focus Area/s: Cancer, Clinical Translation, Prostate, Metabolism
03/17/22
Rahul Aggarwal, MD, Associate Professor of Medicine, UCSF
HMTRC Workshop 2022
Emerging Clinical Applications of Hyperpolarized 13C MRI in Prostate Cancer
(20 min)
Focus Area/s: Prostate, Cancer, Clinical Translation
12/07/21
Robert Bok, MD, PhD, Associate Professor, UCSF
International HP C-13 MRI Seminar
Applications of HP 13C-MRI in Prostate Cancer - UCSF Experience
(23 min)
Focus Area/s: Clinical Translation, Prostate Cancer
12/07/21
Robert Bok, MD, PhD, Associate Professor, UCSF
International HP C-13 MRI Seminar
Applications of HP 13C-MRI in Prostate Cancer - UCSF Experience
(23 min)
08/01/20
Robert Bok, MD, PhD, Associate Professor, UCSF
Multi-site Collaboration Presentation
Focus Area/s: Clinical Translation - Prostate Cancer
03/06/20
Rahul Aggarwal, MD, Associate Professor of Medicine, UCSF
HMTRC Workshop 2020
Emerging Clinical Applications of HP 13C MRI in Prostate Cancer
(25 min)
Focus Area/s: Clinical Translation - Prostate Cancer
Back to Clinical Translation (by Body Area)
Thyroid
09/28/21
James Bankson, PhD, Professor, MD Anderson Medicine
International HP C-13 MRI Seminar
Assessing Response to Therapy in Patients with Anaplastic Thyroid Cancer
(26 min)
Focus Area/s: HP C-13 Acquisition Development & Analysis, Clinical Translation - Thyroid Cancer
Back to Clinical Translation (by Body Area)