2025 Hyperpolarized MRI Course
Course Details:
Organizers & Instructors:
Jeremy Gordon, PhD
Associate Professor
[email protected]
Renuka Sriram, PhD
Assistant Professor
[email protected]
Additional Lecturers:
Adam Autry, PhD
Specialist
[email protected]
Hsin-Yu Chen, PhD
Senior Bioengineer
[email protected]
Yaewon Kim, PhD
Senior Bioengineer
[email protected]
Aditya Jhajharia
Specialist
[email protected]
Peder Larson, PhD
Professor
[email protected]
Xiaoxi Liu, PhD
Postdoctoral Scholar
[email protected]
Avantika Sinha
Graduate Student
[email protected]
Celine Taglang, PhD
Associate Specialist
[email protected]
Tamara Vasilkovska, MD, PhD
Postdoctoral Scholar
[email protected]
Pavithra Viswanath, PhD
Associate Professor
[email protected]
Minjie Zhu, PhD
Postdoctoral Scholar
[email protected]
Administrative Support:
Jenny Che
Program Officer
Contact for: Course Administrative Oversight
[email protected]
Jenna Bernard, PhD
Data Scientist & Communication Manager
Contact for: Course Website & Virtual Meetings
[email protected]
Cresini Tabaranza-David
Executive Analyst
Contact for In-person Room Support
[email protected]
Phone: (415) 514-4450
Course Description:
Hyperpolarized NMR and MRI is an emerging modality that can be used to study biochemical reactions, including metabolic conversion, as well as pH, redox potential, perfusion, transport, and more. It has promising clinical applications for cancer imaging, as well as potential for novel experiments in pre-clinical models and cells. This modality is enabled by the development of Dissolution Dynamic Nuclear Polarization (DNP), which requires specialized equipment to prepare a hyperpolarized solution for experiments. This course covers the mechanisms behind Dissolution DNP and experimental considerations. Attendance in this course and completion of a practical hyperpolarizer exam for HyperSense, SpinAligner, and/or SPINlab operation is required to use these DNP polarizers at UCSF. *The HP MRI Book titled "Hyperpolarized Carbon-13 Magnetic Resonance Imaging and Spectroscopy" Academic Press, Elsevier 2021 editor: Dr. Peder Larson is available for purchase online.
Course Materials
Lecture 1:
Air Date: June 17th 2025
Topic: Introduction and DNP Physics
Lecturers:
Renuka Sriram, PhD, Assistant Professor
Presentation Recording:
(46 min)
Reference Materials:
HP MRI Book - Chapter 1 DNP Physics*
HP MRI Book - Chapter 2 DNP Hardware*
HP MRI Book - Chapter 3 Acquisition Methods*
Lecture 2:
Air Date: June 24th 2025
Topic: DNP Hardware - SpinAligner, Hypersense and SPINlab
Lecturer:
Yaewon Kim, PhD, Senior BioEngineer
Presentation Recording:
(48 min)
Reference Materials:
HP MRI Book - Chapter 1 DNP Physics*
HP MRI Book - Chapter 2 DNP Hardware*
HP MRI Book - Chapter 3 Acquisition Methods*
Lecture 3:
Air Date: July 1st 2025
Topic: Hyperpolarized MR Experimental Methods – Cells and Animals
Lecturer:
Aditya Jhajharia, PhD, Specialist
Presentation Recording:
(49 min)
Reference Materials:
HP MRI Book - Chapter 4 Experimental Methods Preclinical*
Lecture 4:
Air Date: July 8th 2025
Topic: DNP Agents
Lecturer:
Celine Taglang PhD, Associate Specialist
Presentation Recording:
(53 min)
Reference Materials:
HP MRI Book - Chapter 6 Agents and Biochemical Interactions*
Lecture 5:
Air Date: July 15th 2025
Topic: MR Acquisition
Lecturer:
Minjie Zhu, PhD, Postdoctoral Scholar
Presentation Recording:
(52 min)
Reference Materials:
HP MRI Book - Chapter 1 DNP Physics*
HP MRI Book - Chapter 2 DNP Hardware*
HP MRI Book - Chapter 3 Acquisition Methods*
Review Articles:
Comparison of acquisition schemes for hyperpolarised ¹³C imaging
Hyperpolarized Metabolic MRI-Acquisition, Reconstruction, and Analysis Methods
Lecture 6:
Air Date: July 22nd 2025
Topic: Hyperpolarized MR Experimental Methods – Human
Lecturer:
Hsin-Yu Chen, PhD, Senior Bioengineer
Presentation Recording: TBD
Reference Materials:
N/A
Lecture 7:
Air Date: July 29th 2025
Topic: Integration of Hyperpolarized MR Into Biomedical Research: Neurological (non-cancer); Cardiac Disease
Lecturers:
Tamara Vasilkovska, MD, PhD, Postdoctoral Scholar
& Avantika Sinha, Graduate Student
Presentation Recording:
(26 min) Neuroscience Presentation
(21 min) Cardiac Presentation
Reference Materials:
HP MRI Book - Chapter 9 Neurological*
HP MRI Book - Chapter 10 Cardiac*
Lecture 8:
Air Date: Aug 5th 2025
Topic: Integration of Hyperpolarized MR Into Biomedical Research: Kidney & Liver Disease
Lecturer:
Xiaoxi Liu, PhD, Postdoctoral Scholar
Presentation Recording:
(51 min)
Reference Materials:
HP MRI Book - Chapter 11 Liver*
Lecture 9:
Air Date: Aug 12th 2025
Topic: Integration of Hyperpolarized MR Into Biomedical Research: Brain Cancer
Lecturers:
Pavithra Viswanath, PhD, Associate Professor
& Adam Autry, PhD, Specialist
Presentation Recording:
(Glioma: 29 min)
Reference Materials:
HP MRI Book - Chapter 8 Cancer*
Lecture 10:
Air Date: Aug 19th 2025
Topic: Hyperpolarized Data Visualization and Analysis
Lecturer:
Peder Larson, PhD, Professor
Presentation Recording:
(1hr 50 min)
Reference Materials:
HP MRI Book - Chapter 7 Analysis and Visualization*