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210 Ma J, Malloy CR, Pena S, Harrison CE, Ratnakar J, Zaha VG, Park JM. Dual-phase imaging of cardiac metabolism using hyperpolarized pyruvate. Magn Reson Med. 2021 Oct 7. doi: 10.1002/mrm.29042. Epub ahead of print. PMID: 34617626.
209 Brender JR, Kishimoto S, Merkle H, Reed G, Hurd RE, Chen AP, Ardenkjaer-Larsen JH, Munasinghe J, Saito K, Seki T, Oshima N, Yamamoto K, Choyke PL, Mitchell J, Krishna MC. Dynamic Imaging of Glucose and Lactate Metabolism by 13C-MRS without Hyperpolarization. Sci Rep. 2019; 9(1):3410. PMCID: PMC6399318.
208 AbuSalim JE, Yamamoto K, Miura N, Blackman B, Brender JR, Mushti C, Seki T, Camphausen KA, Swenson RE, Krishna MC, Kesarwala AH. Simple Esterification of [1-13C]-Alpha-Ketoglutarate Enhances Membrane Permeability and Allows for Noninvasive Tracing of Glutamate and Glutamine Production. ACS Chem Biol. 2021 Sep 23. doi: 10.1021/acschembio.1c00561. Epub ahead of print. PMID: 34554724.
207 Park JM, Josan S, Hurd RE, Graham J, Havel PJ, Bendahan D, Mayer D, Chung Y, Spielman DM, Jue T. Hyperpolarized NMR study of the impact of pyruvate dehydrogenase kinase inhibition on the pyruvate dehydrogenase and TCA flux in type 2 diabetic rat muscle. Pflugers Arch. 2021 Aug 20. doi: 10.1007/s00424-021-02613-3. Epub ahead of print. PMID: 34415396.
206 Chen J, Patel TR, Pinho MC, Choi C, Harrison CE, Baxter JD, Derner K, Pena S, Liticker J, Raza J, Hall RG, Reed GD, Cai C, Hatanpaa KJ, Bankson JA, Bachoo RM, Malloy CR, Mickey BE, Park JM. Preoperative imaging of glioblastoma patients using hyperpolarized 13C pyruvate: Potential role in clinical decision making. Neurooncol Adv. 2021 28;3(1):vdab092. PMCID: PMC8331053.
205 Ragavan M, McLeod MA, Giacalone AG, Merritt ME. Hyperpolarized Dihydroxyacetone Is a Sensitive Probe of Hepatic Gluconeogenic State. Metabolites. 2021 Jul 5;11(7):441. doi: 10.3390/metabo11070441. PMCID: PMC8307483.
204 Blazey, T, Reed, GD, Garbow, JR, von Morze C. Metabolite-Specific Echo-Planar Imaging of Hyperpolarized [1-13C]Pyruvate at 4.7 T. Tomography. 2021; 7(3):466-476. PMCID: PMC8482109
203 Qin H, Tang S, Riselli AM, Bok RA, Delos Santos R, van Criekinge M, Gordon JW, Aggarwal R, Chen R, Goddard G, Zhang CT, Chen A, Reed G, Ruscitto DM, Slater J, Sriram R, Larson PEZ, Vigneron DB, Kurhanewicz J.  Clinical translation of hyperpolarized 13C pyruvate and urea MRI for simultaneous metabolic and perfusion imaging.  Magn Reson Med. 2021 Aug 10. doi: 10.1002/mrm.28965. PMID: 34374471
202 Li Y, Vigneron DB, Xu D. Current human brain applications and challenges of dynamic hyperpolarized carbon-13 lableled pyruvate MR metabolic imaging.  Eur J Nucl Med Mol Imaging. 2021 Aug 25. doi: 10.1007/s00259-021-05508-8. PMID: 34432118
201 Miura N, Mushti C, Sail D, AbuSalim JE, Yamamoto K, Brender JR, Seki T, AbuSalim DI, Matsumoto S, Camphausen KA, Krishna MC, Swenson RE, Kesarwala AH. Synthesis of [1-13C-5-12C]-alpha-ketoglutarate enables noninvasive detection of 2-hydroxyglutarate. NMR Biomed. 2021; 34(11):e4588. PMCID: PMC8492538
200 Harlan CJ, Xu Z, Walker CM, Michel KA, Reed GD, Bankson JA. The Effect of Transmit B1 Inhomogeneity on Hyperpolarized [1-13C]-Pyruvate Metabolic MR Imaging Biomarkers. Med Phys. 2021; 48(9):4900-4908. PMCID: PMC8486175
199 Larson PEZ, Gordon JW. Hyperpolarized Metabolic MRI-Acquisition, Reconstruction, and Analysis Methods. Metabolites. 2021; 11(6):386.PMCID: PMC8231874
198 Park JM, Harrison CE, Ma J, Chen J, Ratnakar J, Zun Z, Liticker J, Reed GD, Chhabra A, Haller RG, Jue T, Malloy CR. Hyperpolarized 13C MR Spectroscopy Depicts in Vivo Effect of Exercise on Pyruvate Metabolism in Human Skeletal Muscle. Radiology. 2021; 300(3):626-632. PMCID: PMC8409104.
197 Yamamoto K, Opina A, Sail D, Blackman B, Saito K, Brender JR, Malinowski RM, Seki T, Oshima N, Crooks DR, Kishimoto S, Saida Y, Otowa Y, Choyke PL, Ardenkjær-Larsen JH, Mitchell JB, Linehan WM, Swenson RE, Krishna MC. Real-Time insight into in vivo redox status utilizing hyperpolarized [1-13C] N-acetyl cysteine. Sci Rep. 2021; 11(1):12155. PMCID: PMC8190077
196 Saida Y, Brender JR, Yamamoto K, Mitchell JB, Krishna MC, Kishimoto S. Multimodal molecular imaging detects early responses to immune checkpoint blockade. Cancer Res. 2021; 81(13): 3693-3705. PMCID: PMC8277685
195 Lee PM, Chen HY, Gordon JW, Zhu Z, Larson PEZ, Dwork N, Van Criekinge M, Carvajal L, Ohliger MA, Wang ZJ, Xu D, Kurhanewicz J, Bok RA, Aggarwal R, Munster PN, Vigneron DB. Specialized computational methods for denoising, B1 correction, and kinetic modeling in hyperpolarized 13C MR EPSI studies of liver tumors. Magn Reson Med. 2021 Jul 3. doi: 10.1002/mrm.28901. Epub ahead of print. PMID: 34216051
194 Kim Y, Chen HY, Autry AW, Villanueva-Meyer J, Chang SM, Li Y, Larson PEZ, Brender JR, Krishna MC, Xu D, Vigneron DB, Gordon JW. Denoising of hyperpolarized 13C MR images of the human brain using patch-based higher-order singular value decomposition. Magn Reson Med. 2021 Jun 25. doi: 10.1002/mrm.28887. Epub ahead of print. PMID: 34173268
193 Kawai T, Brender JR, Lee JA, Kramp T, Kishimoto S, Krishna MC, Tofilon P, Camphausen KA. Detection of metabolic change in glioblastoma cells after radiotherapy using hyperpolarized 13C-MRI. NMR Biomed. 2021;34(7):e4514. PMCID: PMC8243917
192 Batsios G, Taglang C, Cao P, Gillespie AM, Najac C, Subramani E, Wilson DM, Flavell RR, Larson PEZ, Ronen SM, Viswanath P. Imaging 6-Phosphogluconolactonase Activity in Brain Tumors In Vivo Using Hyperpolarized δ-[1-13C]gluconolactone. Front Oncol. 2021;11:589570. PMCID: PMC8082394
191 Lv X, Walton JH, Druga E, Wang F, Aguilar A, McKnelly T, Nazaryan R, Liu FL, Wu L, Shenderova O, Vigneron DB, Meriles CA, Reimer JA, Pines A, Ajoy A. Background-free dual-mode optical and 13C magnetic resonance imaging in diamond particles. Proc Natl Acad Sci USA. 2021;118(21):e2023579118. PMCID: PMC8166172
190 Bøgh N, Olin RB, Hansen ES, Gordon JW, Bech SK, Bertelsen LB, Sánchez-Heredia JD, Blicher JU, Østergaard L, Ardenkjær-Larsen JH, Bok RA, Vigneron DB, Laustsen C. Metabolic MRI with hyperpolarized [1-13C]pyruvate separates benign oligemia from infarcting penumbra in porcine stroke. J Cereb Blood Flow Metab. 2021 May 20:271678X211018317. doi: 10.1177/0271678X211018317. Epub ahead of print. PMID: 34013807
189 Viswanath P, Batsios G, Ayyappan V, Taglang C, Gillespie AM, Larson PEZ, Luchman HA, Costello JF, Pieper RO, Ronen SM. Metabolic imaging detects elevated glucose flux through the pentose phosphate pathway associated with TERT expression in low-grade gliomas. Neuro Oncol. 2021; 23(9):1509-1522. PMCID: PMC8408874
188 Ma J, Chen J, Reed GD, Hackett EP, Harrison CE, Ratnakar J, Schulte RF, Zaha VG, Malloy CR, Park JM. Cardiac T2* measurement of hyperpolarized 13C metabolites using metabolite-selective multi-echo spiral imaging. Magn Reson Med. 2021; 86(3):1494-1504. PMCID: PMC8212421
187 Tang S, Meng MV, Slater JB, Gordon JW, Vigneron DB, Stohr BA, Larson PEZ, Wang ZJ. Metabolic imaging with hyperpolarized 13C pyruvate magnetic resonance imaging in patients with renal tumors-Initial experience. Cancer. 2021; 127(15): 2693-2704. PMID: 33844280


Le Page LM, Guglielmetti C, Najac CF, Tiret B, Chaumeil MM. Hyperpolarized 13C magnetic resonance spectroscopy detects toxin-induced neuroinflammation in mice. NMR Biomed. 2019; 32(11):e4164. PMCID: PMC6817388

185 Dwork N, Gordon JW, Tang S, O'Connor D, Hansen ESS, Laustsen C, Larson PEZ. Di-chromatic interpolation of magnetic resonance metabolic images. MAGMA. 2021; 34(1):57-72. PMCID: PMC7983744 


Sun J, Bok RA, DeLos Santos J, Upadhyay D, DeLos Santos R, Agarwal S, Van Criekinge M, Vigneron DB, Aggarwal R, Peehl DM, Kurhanewicz J, Sriram R. Resistance to Androgen Deprivation Leads to Altered Metabolism in Human and Murine Prostate Cancer Cell and Tumor Models. Metabolites. 2021;11(3):139. PMCID: PMC7996870

183 Reed GD, Ma J, Park JM, Schulte RF, Harrison CE, Chen AP, Pena S, Baxter J, Derner K, Tai M, Raza J, Liticker J, Hall RG 2nd, Dean Sherry A, Zaha VG, Malloy CR. Characterization and compensation of f0 inhomogeneity artifact in spiral hyperpolarized 13C imaging of the human heart. Magn Reson Med. 2021; 86(1):157-166. PMCID: PMC8049085
182 Ahamed F, Van Criekinge M, Wang ZJ, Kurhanewicz J, Larson P, Sriram R. Modeling hyperpolarized lactate signal dynamics in cells, patient-derived tissue slice cultures and murine models. NMR Biomed. 2021 Jan 7. doi: 10.1002/nbm.4467. Epub ahead of print. PMID: 33415771
181 Mu C, Korenchan DE, Wang S, Wilson DM, Flavell RR. Tumor Microenvironment Biosensors for Hyperpolarized Carbon-13 Magnetic Resonance Spectroscopy. Mol Imaging Biol. 2021 23(3):323-334. PMCID: PMC8105261
180 Viswanath P, Batsios G, Mukherjee J, Gillespie AM, Larson PEZ, Luchman HA, Phillips JJ, Costello JF, Pieper RO, Ronen SM. Non-invasive assessment of telomere maintenance mechanisms in brain tumors. Nat Commun. 2021; 12(1): 92. PMCID: PMC7782549
179 Datta K, Spielman D.  MRI of [2-13C]Lactate without J-coupling artifacts. Magn Reson Med. 2021; 85(3): 1522-1539. PMCID: PMC7718337
178 Ohliger MA, Gordon JW, Carvajal L, Larson PEZ, Ou JJ, Agarwal S, Zhu Z, Vigneron DB, von Morze C.  55Mn-based fiducial markers for rapid and automated RF coil localization for hyperpolarized 13C MRI.  Magn Reson Med. 2021; 85(1):518-530. PMCID: PMC8354199
177 Brender JR, Kishimoto S, Eaton GR, Eaton SS, Saida Y, Mitchell J, Krishna MC. Trehalose as an alternative to glycerol as a glassing agent for in vivo DNP MRI. Magn Reson Med. 2021; 85(1): 42-48. PMID: 32697878
176 2021 Publications (174 and above) 
Autry AW, Park I, Kline C, Chen HY, Gordon JW, Raber S, Hoffman C, Kim Y, Okamoto K, Vigneron DB, Lupo JM, Prados M, Li Y, Xu D, Mueller S. Pilot Study of Hyperpolarized 13C Metabolic Imaging in Pediatric Patients with Diffuse Intrinsic Pontine Glioma and Other CNS Cancers. Am J Neuroradiol. 2021; 42(1):178-184. PMCID: PMC7814790
175 Rai G, Urban DJ, Mott BT, Hu X, Yang SM, Benavides GA, Johnson MS, Squadrito GL, Brimacombe KR, Lee TD, Cheff DM, Zhu H, Henderson MJ, Pohida K, Sulikowski GA, Dranow DM, Kabir M, Shah P, Padilha E, Tao D, Fang Y, Christov PP, Kim K, Jana S, Muttil P, Anderson T, Kunda NK, Hathaway HJ, Kusewitt DF, Oshima N, Cherukuri M, Davies DR, Norenberg JP, Sklar LA, Moore WJ, Dang CV, Stott GM, Neckers L, Flint AJ, Darley-Usmar VM, Simeonov A, Waterson AG, Jadhav A, Hall MD, Maloney DJ. Pyrazole-Based Lactate Dehydrogenase Inhibitors with Optimized Cell Activity and Pharmacokinetic Properties. J Med Chem. 2020; 63(19): 10984-11011. PMCID: PMC7830743
174 Subramani E, Radoul M, Najac C, Batsios G, Molloy AR, Hong D, Gillespie AM, Santos RD, Viswanath P, Costello JF, Pieper RO, Ronen SM. Glutamate Is a Noninvasive Metabolic Biomarker of IDH1-Mutant Glioma Response to Temozolomide Treatment. Cancer Res. 2020; 80(22): 5098-5108. PMCID: PMC7669718
173 Park JM, Reed GD, Liticker J, Putnam WC, Chandra A, Yaros K, Afzal A, MacNamara JP, Raza J, Hall RG, Baxter J, Derner K, Pena S, Kallem RR, Subramanyan I, Edpuganti V, Harrison C, Muthukumar A, Lewis C, Reddy S, Unni N, Klemow D, Syed S, Li HC, Cole SM, Froehlich T, Ayers CR, de Lemos JA, Malloy CR, Haley B, Zaha VG. Effect of Doxorubicin on Myocardial Bicarbonate Production from Pyruvate Dehydrogenase in Women with Breast Cancer. Circ Res. 2020; 4;127(14):1568-1570. PMCID: PMC7874930
172 Mikrogeorgiou A, Chen Y, Lee BS, Bok R, Sheldon AR, Barkovich JA, Xu D, Ferriero DM. A Metabolomics Study of Hypoxia Ischemia during Mouse Brain Development Using Hyperpolarized 13C.  Dev Neurosci. 2020; 42(1): 49-58. PMCID: PMC7497410
171 Walker CM, Gordon JW, Xu Z, Michel KA, Li L, Larson PEZ, Vigneron DB, Bankson JA.  Slice profile effects on quantitative analysis of hyperpolarized pyruvate.  NMR Biomed. 2020; 33(10): e4373. PMCID: PMC7484340
170 Molloy AR, Najac C, Viswanath P, Lakhani A, Subramani E, Batsios G, Radoul M, Gillespie AM, Pieper RO, Ronen SM. MR-detectable metabolic biomarkers of response to mutant IDH inhibition in low-grade glioma. Theranostics. 2020; 10(19): 8757-8770. PMCID: PMC7392019
169 Gordon JW, Autry AW, Tang S, Graham JY, Bok RA, Zhu X, Villanueva-Meyer JE, Li Y, Ohliger MA, Abraham MR, Xu D, Vigneron DB. Larson PEZ.  A variable resolution approach for improved acquisition of hyperpolarized 13C metabolic MRI.  Magn Reson Med. 2020; 84(6): 2943-2952.  PMCID: PMC7719570
168 Autry AW, Gordon JW, Chen HY, LaFontaine M, Bok R, Van Criekinge M, Slater JB, Carvajal L, Villanueva-Meyer JE, Chang SM, Clarke JL, Lupo JM, Xu D, Larson PEZ, Vigneron DB, Li Y. Characterization of serial hyperpolarized 13C metabolic imaging in patients with glioma. Neuroimage Clin. 2020; 27: 102323. PMCID: PMC7334458
167 Chen HY, Autry AW, Brender JR, Kishimoto S, Krishna MC, Vareth M, Bok RA, Reed GD, Carvajal L, Gordon JW, van Criekinge M, Korenchan DE, Chen AP, Xu D, Li Y, Chang SM, Kurhanewicz J, Larson PEZ, Vigneron DB.  Tensor image enhancement and optimal multichannel receiver combination analyses for human hyperpolarized 13C MRSI. Magn Reson Med. 2020; 84(6): 3351-3365. PMCID: PMC7718428
166 Le Page LM, Guglielmetti C, Taglang C, Chaumeil MM. Imaging Brain Metabolism Using Hyperpolarized 13C Magnetic Resonance Spectroscopy. Trends Neurosci. 2020; 43(5): 343-354. PMCID: PMC7255622.


Batsios G, Najac C, Cao P, Viswanath P, Subramani E, Saito Y, Gillespie AM, Yoshihara HAI, Larson P, Sando S, Ronen SM. In vivo detection of y-glutamyl-transferase up-regulation in glioma using hyperpolarizedy-glutamyl-[1-13C]glycine. Sci Rep. 2020; 10(1): 6244. PMCID: PMC7148357


Qin H, Zhang V, Bok RA, Santos RD, Cunha JA, Hsu IC, Santos JD, Lee JE, Sukumar S, Larson PEZ, Vigneron DB, Wilson DM, Sriram R, Kurhanewicz J.  Simultaneous metabolic and perfusion imaging using hyperpolarized 13C MRI can evaluate early and dose-dependent responses to radiotherapy in a prostate cancer mouse model.  Int J Radiat Oncol Biol Phys.  2020; 107(5): 887-896. PMCID: PMC7381368


Crane JC, Gordon JW, Chen HY, Autry AW, Li Y, Olson MP, Kurhanewicz J, Vigneron DB, Larson PEZ, Xu D. Hyperpolarized 13C MRI data acquisition and analysis in prostate and brain at University of California, San Francisco. NMR Biomed. 2021; 34(5): e4280. PMCID: PMC7501204


Gordon JW, Chen HY, Dwork N, Tang S, Larson PEZ.  Fast Imaging for Hyperpolarized MR Metabolic Imaging. J Magn Reson Imaging. 2021; 53(3):686-702. PMCID: PMC7415658.


Sriram R, Van Criekinge M, DeLos Santos J, Ahamed F, Qin H, Nolley R, Santos RD, Tabatabai ZL, Bok RA, Keshari KR, Vigneron DB, Peehl DM, Kurhanewicz J. Elevated Tumor Lactate and Efflux in High-grade Prostate Cancer demonstrated by Hyperpolarized 13C Magnetic Resonance Spectroscopy of Prostate Tissue Slice Cultures. Cancers (Basel). 2020; 12(3). pii: E537. PMCID: PMC7139946


Tang S, Bok R, Qin H, Reed G, VanCriekinge M, Delos Santos R, Overall W, Santos J, Gordon J, Wang ZJ, Vigneron DB, Larson PEZ. A metabolite-specific 3D stack-of-spiral bSSFP sequence for improved lactate imaging in hyperpolarized [1-13C]pyruvate studies on a 3T clinical scanner. Magn Reson Med. 2020; 84(3):1113-1125. PMCID: PMC7927572.


Milshteyn E, Reed GD, Gordon JW, von Morze C, Cao P, Tang S, Leynes AP, Larson PEZ, Vigneron DB.  Simultaneous T1 and T2 mapping of hyperpolarized 13C compounds using the bSSFP sequence.  J Magn Reson.  2020; 312: 106691. PMCID: PMC7227792


Mammoli D, Gordon J, Autry A, Larson PEZ, Li Y, Chen HY, Chung B, Shin P, Van Criekinge M, Carvajal L, Slater JB, Bok R, Crane J, Xu D, Chang S, Vigneron DB. Kinetic Modeling of Hyperpolarized Carbon-13 Pyruvate Metabolism in the Human Brain. IEEE Trans Med Imaging. 2020; 39(2): 320-327. PMCID: PMC6939147


Chen HY, Aggarwal R, Bok RA, Ohliger MA, Zhu Z, Lee P, Gordon JW, van Criekinge M, Carvajal L, Slater JB, Larson PEZ, Small EJ, Kurhanewicz J, Vigneron DB.  Hyperpolarized 13C-pyruvate MRI detects real-time metabolic flux in prostate cancer metastases to bone and liver: a clinical feasibility study.  Prostate Cancer Prostatic Dis. 2020; 23(2): 269-276. PMCID: PMC7196510

156 2020 Publications (154 and above) 
Lee CY, Soliman H, Geraghty BJ, Chen AP, Connelly KA, Endre R, Perks WJ, Heyn C, Black SE, Cunningham CH. Lactate topography of the human brain using hyperpolarized 13C-MRI. Neuroimage. 2020 Jan 1;204:116202. doi: 10.1016/j.neuroimage.2019.116202. Epub 2019 Sep 23. PMID: 31557546.


Bancroft Brown J, Sriram R, VanCriekinge M, Delos Santos R, Sun J, Tabatabai ZL, Shinohara K, Nguyen H, Peehl DM, Kurhanewicz J. NMR quantification of lactate production and efflux and glutamate fractional enrichment in living human prostate biopsies cultured with [1,6-13C2]glucose. Magn Reson Med. 2019; 82(2): 566-576. PMCID: PMC7150535


Wang S, Korenchan DE, Perez PM, Taglang C, Hayes TR, Sriram R, Bok R, Hong AS, Wu Y, Li H, Wang Z, Kurhanewicz J, Wilson DM, Flavell RR. Amino Acid-Derived Sensors for Specific Zn2+ Detection Using Hyperpolarized 13C Magnetic Resonance Spectroscopy. Chemistry. 2019; 25(51): 11842-11846. PMCID: PMC6742520


Korenchan DE, Bok R, Sriram R, Liu K, Santos RD, Qin H, Lobach I, Korn N, Wilson DM, Kurhanewicz J, Flavell RR. Hyperpolarized in vivo pH imaging reveals grade-dependent acidification in prostate cancer. Oncotarget. 2019; 10(58): 6096-6110. PMCID: PMC6817439


Chung BT, Chen HY, Gordon J, Mammoli D, Sriram R, Autry AW, Le Page LM, Chaumeil M, Shin P, Slater J, Tan CT, Suszczynski C, Chang S, Li Y, Bok RA, Ronen SM, Larson PEZ, Kurhanewicz J, Vigneron DB. First hyperpolarized [2-13C]pyruvate MR studies of human brain metabolism. J Magn Reson. 2019; 309:106617. PMCID: PMC6880930


Barskiy DA, Tayler MCD, Marco-Rius I, Kurhanewicz J, Vigneron DB, Cikrikci S, Aydogdu A, Reh M, Pravdivtsev AN, Hovener JB, Blanchard JW, Wu T, Budker D, Pines A. Zero-field nuclear magnetic resonance of chemically exchanging systems. Nat Commun. 2019; 10(1): 3002. PMCID: PMC6611813


Behr SC, Aggarwal R, VanBrocklin HF, Flavell RR, Gao K, Small EJ, Blecha J, Jivan S, Hope TA, Simko JP, Kurhanewicz J, Noworolski SM, Korn NJ, De Los Santos R, Cooperberg MR, Carroll PR, Nguyen HG, Greene KL, Langton-Webster B, Berkman CE, Seo Y. Phase I Study of CTT1057, an 18F-Labeled Imaging Agent with Phosphoramidate Core Targeting Prostate-Specific Membrance Antigen in Prostate Cancer. J Nucl Med. 2019; 60(7): 910-916. PMCID: PMC6604687


Korenchan DE, Gordon JW, Sukumar S, Sriram R, Baligand C, Van Criekinge M, Bok R, Vigneron DB, Wilson DM, Larson PEZ, Kurhanewicz J, Flavell RR. Using bidirectional chemical exchange for improved hyperpolarized [13C]bicarbonate pH imaging. Magn Reson Med. 2019; 82(3): 959-972. PMCID: PMC6559833


Autry AW, Gordon JW, Carvajal L, Mareyam A, Chen HY, Park I, Mammoli D, Vareth M, Chang SM, Wald LL, Xu D, Vigneron DB, Nelson SJ, Li Y. Comparison between 8- and 32-channel phased array receive coils for in vivo hyperpolarized 13C imaging of the human brain. Magn Reson Med. 2019; 82(2): 833-841. PMCID: PMC6612511


Radoul M, Najac C, Viswanath P, Mukherjee J, Kelly M, Gillespie AM, Chaumeil MM, Eriksson P, Delos Santos R, Pieper RO, Ronen SM. HDAC inhibition in glioblastoma monitored by hyperpolarized 13C MRSI. NMR Biomed. 2019; 32(2): e4044. PMCID: PMC6545173


Najac C, Radoul M, Le Page LM, Batsios G, Subramani E, Viswanath P, Gillespie AM, Ronen SM. In vivo investigation of hyperpolarized [1,3-13C2]acetoacetate as a metabolic probe in normal brain and in glioma. Sci Rep. 2019; 9(1): 3402. PMCID: PMC6399277


Zhu X, Gordon JW, Bok RA, Kurhanewicz J, Larson PEZ. Dynamic diffusion-weighted hyperpolarized 13C imaging based on a slice-selective double spin echo sequence for measurements of cellular transport. Magn Reson Med. 2019; 81(3): 2001-2010. PMCID: PMC6347546


Zhu Z, Zhu X, Ohliger MA, Tang S, Cao P, Carvajal L, Autry AW, Li Y, Kurhanewicz J, Chang S, Aggarwal R, Munster P, Xu D, Larson PEZ, Vigneron DB, Gordon JW. Coil combination methods for multi-channel hyperpolarized 13C imaging data from human studies. J Magn Rson. 2019; 301: 73-79. PMCID: PMC7170546


Wang ZJ, Ohliger MA, Larson PEZ, Gordon JW, Bok RA, Slater J, Villanueva-Meyer JE, Hess CP, Kurhanewicz J, Vigneron DB. Hyperpolarized 13C MRI: State of the Art and Future Directions. Radiology. 2019; 291(2): 273-284. PMCID: PMC6490043


Bok R, Lee J, Sriram R, Keshari K, Sukumar S, Daneshmandi S, Korenchan DE, Flavell RR, Vigneron DB, Kurhanewicz J, Seth P. The Role of Lactate Metabolism in Prostate Cancer Progression and Metastases Revealed by Dual-Agent Hyperpolarized 13C MRSI. Cancers (Basel). 2019; 11(2). PMCID: PMC6406929


Walker CM, Fuentes D, Larson PEZ, Kundra V, Vigneron DB, Bankson JA. Effects of excitation angle strategy on quantitative analysis of hyperpolarized pyruvate. Magn Reson Med. 2019; 81(6): 3754-3762. PMCID: PMC6435389


Chen HY, Gordon JW, Bok RA, Cao P, von Morze C, van Criekinge M, Milshteyn E, Carvajal L, Hurd RE, Kurhanewicz J, Vigneron DB, Larson PEZ. Pulse sequence considerations for quantification of pyruvate-to-lactate conversion kPL in hyperpolarized 13C imaging. NMR Biomed. 2019; 32(3): e4052. PMCID: PMC6380928


Tang SJ, Milshteyn E, Reed G, Gordon J, Bok R, Zhu X, Zhu Z, Vigneron DB, Larson PEZ. A regional bolus tracking and real-time B1 calibration method for hyperpolarized 13C MRI. Magn Reson Med. 2019; 81(2): 839-851. PMCID: PMC6289616


Gordon JW, Chen HY, Autry A, Park I, Van Criekinge M, Mammoli D, Milshteyn E, Bok R, Xu D, Li Y, Aggarwal R, Chang S, Slater JB, Ferrone M, Nelson S, Kurhanewicz J, Larson PEZ, Vigneron DB. Translation of Carbon-13 EPI for hyperpolarized MR molecular imaging of prostate and brain cancer patients. Magn Reson Med. 2019; 81(4): 2702-2709. PMCID: PMC6372313


Kurhanewicz J, Vigneron DB, Ardenkjaer-Larsen JH, Bankson JA, Brindle K, Cunningham CH, Gallagher FA, Keshari KR, Kjaer A, Laustsen C, Mankoff DA, Merritt ME, Nelson SJ, Pauly JM, Lee P, Ronen S, Tyler DJ, Rajan SS, Spielman DM, Wald L, Zhang X, Malloy CR, Rizi R. Hyperpolarized 13C MRI: Path to Clinical Translation in Oncology. Neoplasia. 2019; 21(1): 1-16. PMCID: PMC6260457

136 2019 Publications (134 and above) 
Lee JE, Diederich CJ, Bok R, Sriram R, Santos RD, Noworolski SM, Salgaonkar VA, Adams MS, Vigneron DB, Kurhanewicz J. Assessing high-intensity focused ultrasound treatment of prostate cancer with hyperpolarized 13C dual-agent imaging of metabolism and perfusion. NMR Biomed. 2019; 32(10): e3962. PMCID: PMC6338537
135 Korenchan DE, Flavell RR. Spatiotemporal pH Heterogeneity as a Promoter of Cancer Progression and Therapeutic Resistance. Cancers (Basel). 2019;11(7):1026. PMCID: PMC6678451.


Sriram R, Sun J, Villanueva-Meyer J, Mutch C, Delos Santos J, Peters J, Korenchan DE, Neumann K, Van Criekinge M, Kurhanewicz J, Rosenberg O, Wilson D, Ohliger MA. Detection of Bacteria-Specific Metabolism Using Hyperpolarized [2-13C]Pyruvate. ACS Infect Dis. 2018; 4(5): 797-805. PMCID: PMC6008482


Sriram R, Nguyen J, Santos JD, Nguyen L, Sun J, Vigneron S, Van Criekinge M, Kurhanewicz J, MacKenzie JD. Molecular detection of inflammation in cell models using hyperpolarized 13C pyruvate. Theranostics. 2018; 8(12): 3400-3407. PMCID: PMC6010986


Qin H, Carroll VN, Sriram R, Villanueva-Meyer JE, von Morze C, Wang ZJ, Mutch CA, Keshari KR, Flavell RR, Kurhanewicz J, Wilson DM. Imaging glutathione depletion in the rat brain using ascorbate-derived hyperpolarized MR and PET probes. Sci Rep. 2018; 8(1): 7928. PMCID: PMC5962598


Truillet C, Parker MFL, Huynh LT, Wei J, Jami KM, Wang YH, Shen YS, Sriram R, Wilson DM, Kurhanewicz J, Evans MJ. Measuring glucocorticoid receptor expression in vivo with PET. Oncotarget. 2018; 9(29): 20399-20408. PMCID: PMC5945515


Larson PEZ, Chen HY, Gordon JW, Korn N, Maidens J, Arcak M, Tang S, van Criekinge M, Carvajal L, Mammoli D, Bok R, Aggarwal R, Ferrone M, Slater JB, Nelson SJ, Kurhanewicz J, Vigneron DB. Investigation of analysis methods for hyperpolarized 13C-pyruvate metabolic MRI in prostate cancer patients. NMR Biomed. 2018; 31(11): e3997. PMCID: PMC6392436


Sriram R, Gordon J, Baligand C, Ahamed F, Delos Santos J, Qin H, Bok RA, Vigneron DB, Kurhanewicz J, Larson PEZ, Wang ZJ. Non-Invasive Assessment of Lactate Production and Compartmentalization in Renal Cell Carcinomas Using Hyperpolarized 13C Pyruvate MRI. Cancers (Basel). 2018; 10(9). PMCID: PMC6162434


Autry AW, Hashizume R, James CD, Larson PEZ, Vigneron DB, Park I. Measuring Tumor Metabolism in Pediatric Diffuse Intrinsic Pontine Glioma Using Hyperpolarized Carbon-13 MR Metabolic Imaging. 2018; 2018: 3215658. PMCID: PMC6098895


Maidens J, Gordon JW, Chen HY, Park I, Van Criekinge M, Milshteyn E, Bok R, Aggarwal R, Ferrone M, Slater JB, Kurhanewicz J, Vigneron DB, Arcak M, Larson PEZ. Spatio-temporally constrained reconstruction for hyperpolarized carbon-13 MRI using kinetic models. IEEE Trans Med Imaging. 2018; 31(12): 2603-2612. PMCID: PMC6279499


Li N, Liu S, Hu X, Luo C, Zhang X, Li Y. Electromagnetic Field and Radio Frequency Circuit Co-Simulation for Magnetic Resonance Imaging Dual-Tuned Radio Frequency Coils. IEEE Trans Magn. 2018; 54(3). PMCID: PMC5947962


Taglang C, Korenchan DE, von Morze C, Yu J, Najac C, Wang S, Blecha JE, Subramaniam S, Bok R, VanBrocklin HF, Vigneron DB, Ronen SM, Sriram R, Kurhanewicz J, Wilson DM, Flavell RR. Late-Stage deuteration of 13C-enriched substrates for T1 prolongation in hyperpolarized 13C MRI. Chem Commun (Camb). 2018; 54(41): 5233-5236. PMCID: PMC6054790


Jiang W, Larson PEZ, Lustig M. Simultaneous Auto-calibration and Gradient Delays Estimation (SAGE) in non-Cartesian Parallel MRI using Low-rank Constraints. Magn Reson Med. 2018; 80(5): 2006-2016. PMCID: PMC6107389


Chen HY, Larson PEZ, Gordon JW, Bok RA, Ferrone M, van Criekinge M, Carvajal L, Cao P, Pauly JM, Kerr AB, Park I, Slater JB, Nelson SJ, Munster PN, Aggarwal R, Kurhanewicz J, Vigneron DB. Technique development of 3D dynamic CS-EPSI for hyperpolarized 13C pyruvate MR molecular imaging of human prostate cancer. Magn Reson Med. 2018; 80(5): 2062-2072. PMCID: PMC6107425


Milshteyn E, von Morze C, Reed GD, Shang H, Shin PJ, Larson PEZ, Vigneron DB. Using a local low rank plus sparse reconstruction to accelerate dynamic hyperpolarized 13C imaging using the bSSFP sequence. J Magn Reson. 2018; 290: 46-59. PMCID: PMC6054792


von Morze C, Reed GD, Larson PE, Mammoli D, Chen AP, Tropp J, Van Criekinge M, Ohliger MA, Kurhanewicz J, Vigneron DB, Merritt ME. In vivo hyperpolarization transfer in a clinical MRI scanner. Magn Reson Med. 2018; 80(2): 480-487. PMCID: PMC5910192


Gordon JW, Hansen RB, Shin PJ, Feng Y, Vigneron DB, Larson PEZ. 3D hyperpolarized C-13 EPI with calibrationless parallel imaging. J Magn Reson. 2018; 289: 92-99. PMCID: PMC5856653


Milshteyn E, von Morze C, Gordon JW, Zhu Z, Larson PEZ, Vigneron DB. High spatiotemporal resolution bSSFP imaging of hyperpolarized [1-13C]pyruvate and [1-13C]lactate with spectral suppression of alanine and pyruvate-hydrate. Magn Reson Med. 2018; 80(3): 1048-1060. PMCID: PMC5980670


von Morze C, Allu PKR, Chang GY, Marco-Rius I, Milshteyn E, Wang ZJ, Ohliger MA, Gleason CE, Kurhanewicz J, Vigneron DB, Pearce D. Non-invasive detection of divergent metabolic signals in insulin deficiency vs. insulin resistance. Sci Rep. 2018; 8(1): 2088. PMCID: PMC5794967


Park I, Larson PEZ, Gordon JW, Carvajal L, Chen HY, Bok R, Van Criekinge M, Ferrone M, Slater JB, Xu D, Kurhanewicz J, Vigneron DB, Chang S, Nelson SJ. Development of methods and feasibility of using hyperpolarized carbon-13 imaging data for evaluating brain metabolism in patient studies. Magn Reson Med. 2018; 80(3): 864-873. PMCID: PMC5980662


von Morze C, Ohliger MA, Marco-Rius I, Wilson DM, Flavell RR, Pearce D, Vigneron DB, Kurhanewicz J, Wang ZJ. Direct assessment of renal mitochondrial redox state using hyperpolarized 13C-acetoacetate. Magn Reson Med. 2018; 79(4): 1862-1869. PMCID: PMC5815327


von Morze C, Tropp J, Chen AP, Marco-Rius I, Van Criekinge M, Skloss TW, Mammoli D, Kurhanewicz J, Vigneron DB, Ohliger MA, Merritt ME. Sensitivity enhancement for detection of hyperpolarized 13C MRI probes with 1H spin coupling introduced by enzymatic transformation in vivo. Magn Reson Med. 2018; 80(1): 36-41. PMCID: PMC5876091

114 2018 Publications (113 and above) 
Marco-Rius I, Gordon JW, Mattis AN, Bok R, Delos Santos R, Sukumar S, Larson PEZ, Vigneron DB, Ohliger MA. Diffusion-weighted imaging of hyperpolarized [13C]urea in mouse liver. J Magn Reson Imaging. 2018; 47(1): 141-151. PMCID: PMC5645231


Baligand C, Qin H, True-Yasaki A, Gordon JW, von Morze C, Santos JD, Wilson DM, Raffai R, Cowley PM, Baker AJ, Kurhanewicz J, Lovett DH, Wang ZJ. Hyperpolarized 13C magnetic resonance evaluation of renal ischemia reperfusion injury in a murine model. NMR Biomed. 2017; 30(10). PMCID: PMC5618802


Guglielmetti C, Najac C, Didonna A, Van der Linden A, Ronen SM, Chaumeil MM. Hyperpolarized 13C MR metabolic imaging can detect neuroinflammation in vivo in a multiple sclerosis murine model. Proc Natl Acad Sci USA. 2017; 114(33): E6982-E6991. PMCID: PMC5565402


Aggarwal R, Vigneron DB, Kurhanewicz J. Hyperpolarized 1-[13C]-Pyruvate Magnetic Resonance Imaging Detects an Early Metabolic Response to Androgen Ablation Therapy in Prostate Cancer. Eur Urol. 2017; 72(6): 1028-1029. PMCID: PMC5723206


Shin PJ, Zhu Z, Camarda R, Bok RA, Zhou AY, Kurhanewicz J, Goga A, Vigneron DB. Cancer recurrence monitoring using hyperpolarized [1-13C]pyruvate metabolic imaging in murine breast cancer model. Magn Reson Imaging. 2017; 43: 105-109. PMCID: PMC5632580


Chen HY, Larson PEZ, Bok RA, von Morze C, Sriram R, Delos Santos R, Delos Santos J, Gordon JW, Bahrami N, Ferrone M, Kurhanewicz J, Vigneron DB. Assessing Prostate Cancer Aggressiveness with Hyperpolarized Dual-Agent 3D Dynamic Imaging of Metabolism and Perfusion. Cancer Res. 2017; 77(12): 3207-3216. PMCID: PMC5484421


Korenchan DE, Taglang C, von Morze C, Blecha JE, Gordon JW, Sriram R, Larson PEZ, Vigneron DB, VanBrocklin HF, Kurhanewicz J, Wilson DM, Flavell RR. Dicarboxylic acids as pH sensors for hyperpolarized 13C magnetic resonance spectroscopic imaging. Analyst. 2017; 142(9): 1429-1433. PMCID: PMC5462110


Milshteyn E, von Morze C, Reed GD, Shang H, Shin PJ, Zhu Z, Chen HY, Bok R, Goga A, Kurhanewicz J, Larson PE, Vigneron DB. Development of high resolution 3D hyperpolarized carbon-13 MR molecular imaging techniques. Magn Reson Imaging. 2017; 38: 152-162. PMCID: PMC5360530


Marco-Rius I, von Morze C, Sriram R, Cao P, Chang GY, Milshteyn E, Bok RA, Ohliger MA, Pearce D, Kurhanewicz J, Larson PE, Vigneron DB, Merritt M. Monitoring acute metabolic changes in the liver and kidneys induced by fructose and glucose using hyperpolarized [2-13C]dihydroxyacetone. Magn Reson Med. 2017; 77(1): 65-73. PMCID: PMC5191913


Shang H, Sukumar S, von Morze C, Bok RA, Marco-Rius I, Kerr A, Reed GD, Milshteyn E, Ohliger MA, Kurhanewicz J, Larson PE, Pauly JM, Vigneron DB. Spectrally selective three-dimensional dynamic balanced steady-state free precession for hyperpolarized C-13 metabolic imaging with spectrally selective radiofrequency pulses. Magn Reson Med. 2017; 78(3): 963-975. PMCID: PMC5400740


Gordon JW, Milshteyn E, Marco-Rius I, Ohliger M, Vigneron DB, Larson PE. Mis-estimation and bias of hyperpolarized apparent diffusion coefficient measurements due to slice profile effects. Magn Reson Med. 2017; 78(3): 1087-1092. PMCID: PMC5391314


Ohliger MA, von Morze C, Marco-Rius I, Gordon J, Larson PE, Bok R, Chen HY, Kurhanewicz J, Vigneron D. Combining hyperpolarized 13C MRI with a liver-specific gadolinium contrast agent for selective assessment of hepatocyte metabolism. Magn Reson Med. 2017; 77(6): 2356-2363. PMCID: PMC5156580


von Morze C, Chang GY, Larson PE, Shang H, Allu PK, Bok RA, Crane JC, Olson MP, Tan CT, Marco-Rius I, Nelson SJ, Kurhanewicz J, Pearce D, Vigneron DB. Detection of localized changes in the metabolism of hyperpolarized gluconeogenic precursors 13C-lactate and 13C-pyruvate in kidney and liver. Magn Reson Med. 2017; 77(4): 1429-1437. PMCID: PMC5074920


Marco-Rius I, Cao P, von Morze C, Merritt M, Moreno KX, Chang GY, Ohliger MA, Pearce D, Kurhanewicz J, Larson PEZ, Vigneron DB. Multiband Spectral-Spatial RF Excitation for Hyperpolarized [2-13C]Dihydroxyacetone 13C-MR Metabolism Studies. Magn Reson Med. 2017; 77(4): 1419-1428. PMCID: PMC5040611


Gordon JW, Vigneron DB, Larson PE. Development of a symmetric echo planar imaging framework for clinical translation of rapid dynamic hyperpolarized 13C imaging. Magn Reson Med. 2017; 77(2): 826-832. PMCID: PMC4992668


2017 Publications (98 and above) 
Park I, von Morze C, Lupo JM, Ardenkjaer-Larsen JH, Kadambi A, Vigneron DB, Nelson SJ. Investigating Tumor Perfusion by Hyperpolarized 13C MRI with Comparison to Conventional Gadolinium Contrast-Enhanced MRI and Pathology in Orthotopic Human GBM Xenografts. Magn Reson Med. 2017; 77(2): 841-847. PMCID: PMC4991955

98 Cao P, Shin PJ, Park I, Najac C, Marco-Rius I, Vigneron DB, Nelson SJ, Ronen SM, Larson PE. Accelerated high-bandwidth MR spectroscopic imaging using compressed sensing. Magn Reson Med. 2016; 76(2): 369-79. PMCID: PMC4945498
97 Reed GD, von Morze C, Verkman AS, Koelsch BL, Chaumeil MM, Lustig M, Ronen SM, Bok RA, Sands JM, Larson PE, Wang ZJ, Larsen JH, Kurhanewicz J, Vigneron DB. Imaging Renal Urea Handling in Rats at Millimeter Resolution using Hyperpolarized Magnetic Resonance Relaxometry. Tomography. 2016; 2(2): 125-135. PMCID: PMC4996281
96 Koelsch BL, Sriram R, Keshari KR, Leon Swisher C, Van Criekinge M, Sukumar S, Vigneron DB, Wang ZJ, Larson PE, Kurhanewicz J. Separation of extra- and intracellular metabolites using hyperpolarized 13C diffusion weighted MR. J Magn Reson. 2016; 270: 115-123. PMCID: PMC5448422
95 Cao P, Zhang X, Park I, Najac C, Nelson SJ, Ronen S, Larson PE. (1) H-(13) C independently tuned radiofrequency surface coil applied for in vivo hyperpolarized MRI. Magn Reson Med. 2016; 76(5): 1612-1620. PMCID: PMC4879596
94 Maidens J, Gordon JW, Arcak M, Larson PEZ. Optimizing flip angles for metabolic rate estimation in hyperpolarized carbon-13 MRI. IEEE Transactions on Medical Imaging. 2016; 35(11): 2403-2412. PMCID: PMC5134417


Sriram R, Van Criekinge M, DeLos Santos J, Keshari KR, Wilson DM, Peehl D, Kurhanewicz J, Wang ZJ. Non-invasive differentiation of benign renal tumors from clear cell renal cell carcinomas using clinically translatable hyperpolarized 13C pyruvate magnetic resonance. Tomography. 2016; 2(1): 35-42. PMCID: PMC4876723


Radoul M, Chaumeil MM, Eriksson P, Wang AS, Phillips JJ, Ronen SM. MR Studies of Glioblastoma Models Treated with Dual PI3K/mTOR Inhibitor and Temozolomide:Metabolic Changes Are Associated with Enhanced Survival. Mol Cancer Ther. 2016; 15(5): 1113-22. PMCID: PMC4873419


Viswanath P, Najac C, Izquierdo-Garcia JL, Pankov A, Hong C, Eriksson P, Costello JF, Pieper RO, Ronen SM. Mutant IDH1 expression is associated with down-regulation of monocarboxylate transporters. Oncotarget. 2016; 7(73): 34942-55. PMCID: PMC5085201


Chaumeil MM, Radoul M, Najac C, Eriksson P, Viswanath P, Blough MD, Chesnelong C, Luchman HA, Cairncross JG, Ronen SM. Hyperpolarized 13C MR imaging detects no lactate production in mutant IDH1 gliomas: Implications for diagnosis and response monitoring. Neuroimage Clin. 2016; 12: 180-9. PMCID: PMC4939422


Najac C, Chaumeil MM, Kohanbash G, Guglielmetti C, Gordon JW, Okada H, Ronen SM. Detection of inflammatory cell function using 13C magnetic resonance spectroscopy of hyperpolarized [6-(13)C]-arginine. Sci Rep. 2016; 6: 3197. PMCID: PMC4979036


Gordon JW, Larson PEZ. Pulse Sequences for Hyperpolarized MRS. eMagRes. 2016, Vol 5: 1229-1246. doi:10.1002/97804700349590.emrstm1451.


Kurhanewicz J, Vigneron DB. Magnetic Resonance Spectroscopy of Prostate Cancer. John Wiley & Sons, Ltd. eMagRes. 2016, Vol 5: 1–22. DOI 10.1002/9780470034590.emrstm1433.


Korenchan DE, Flavell RR, Baligand C, Sriram R, Neumann K, Sukumar S, VanBrocklin H, Vigneron DB, Wilson DM, Kurhanewicz J. Dynamic nuclear polarization of biocompatible 13C-enriched carbonates for in vivo pH imaging. Chem Commun (Camb). 2016; 52(14): 3030-3. PMCID: PMC4864526


Shang H, Larson P, Kerr A, Reed G, Sukumar S, Elkhaled A, Gordon JW, Ohliger MA, Pauly JM, Lustig M, Vigneron DB. Multiband RF Pulses with Improved Performance via Convex Optimization. J Magn Reson. 2016; 262: 81-90. PMCID: PMC4716678


Feng Y, Gordon JW, Shin PJ, von Morze C, Lustig M, Larson PEZ, Ohliger MA, Carvajal L, Tropp J, Pauly JM, Vigneron DB. Development and testing of hyperpolarized 13C MR calibrationless parallel imaging. J Magn Reson. 2016; 262: 1-7. PMCID: PMC4864033


Chen Y, Kim H, Bok R, Sukumar S, Mu X, Sheldon RA, Barkovich AJ, Ferrierro DM, Xu D. Pyruvate to Lactate Metabolic Changes during Neurodevelopment Measured Dynamically Using Hyperpolarized 13C Imaging in Juvenile Murine Brain. Dev Neurosci. 2016; 38(1): 34-40. PMCID: PMC4732911

82 von Morze C, Bok RA, Ohliger MA, Zhu Z, Vigneron DB, Kurhanewicz J. Hyperpolarized [13C]ketobutyrate, a molecular analog of pyruvate with modified specificity for LDH Isoforms. Magn Reson Med. 2016; 75(5): 1894-900. PMCID: PMC4868134
81 Shang H, Skloss T, von Morze C, Carvajal L, Van Criekinge M, Milshteyn E, Larson PE, Hurd RE, Vigneron DB. Handheld electromagnet carrier for transfer of hyperpolarized carbon-13 samples. Magn Reson Med. 2016; 75(2): 917-22. PMCID: PMC4567531
80 2016 Publications (79 and above) 
Jiang W, Lustig M, Larson PE. Concentric rings K-space trajectory for hyperpolarized 13C MR spectroscopic imaging. Magn Reson Med. 2016; 75(1): 19-31. PMCID: PMC4476971
79 Carroll VN, Truillet C, Shen B, Flavell RR, Shao X, Evans MJ, VanBrocklin HF, Scott PJ, Chin FT, Wilson DM. [(11)C]Ascorbic and [(11)C]dehydroascorbic acid, an endogenous redox pair for sensing reactive oxygen species using positron emission tomography. Chem Commun (Camb). 2016; 52(27):4888-90.PMCID: PMC4854297


Keshari KR, Wilson DM, Van Criekinge M, Sriram R, Koelsch BL, Wang ZJ, VanBrocklin HF, Peehl DM, O’Brien T, Sampath D, Carano RA, Kurhanewicz J. Metabolic response of prostate cancer to nicotinamide phophoribosyltransferase inhibition in a hyperpolarized MR/PET compatible bioreactor. Prostate. 2015; 75(14): 1601-9. PMCID: PMC4537380


Flavell RR, von Morze C, Blecha JE, Korenchan D, van Criekinge M, Sriram R, Gordon J, Chen HY, Sukumar S, Bok R, Wang ZJ, Vigneron D, Larson P, Kurhanewicz J, Wilson DM. Application of Good’s buffers to pH imaging using hyperpolarized 13C MRI. Chem Comm (Camb). 2015; 51(74): 14119-22. PMCID: PMC4854286


Sriram R, van Criekinge M, Hansen AF, Wang Z, Vigneron D, Wilson DM, Keshari K, Kurhanewicz J. Real-time Measurement of Hyperpolarized Lactate Production and Efflux as a Biomarker of Tumor Aggressiveness in an MR compatible 3D Cell Culture Bioreactor. NMR Biomed. 2015; 28(9): 1141-9. PMCID: PMC4537810


Leon Swisher C, Koelsch B, Sukumar S, Sriram R, Delos Santos R, Wang ZJ, Kurhanewicz J, Vigneron D, Larson PE. Dynamic UltraFast 2D Exchange Spectroscopy (UF-EXSY) of Hyperpolarized Substrates. JMR. 2015; 257: 102-109. PMCID: PMC4515769


Li Y, Park I, Nelson SJ. Imaging Tumor Metabolism using in vivo MR Spectroscopy. Cancer J. 2015; 21(2): 123-8. PMCID: PMC4429803


Shin P, Larson P, Uecker M, Reed G, Kerr A, Tropp J, Ohliger M, Nelson S, Pauly J, Lustig M, Vigneron D. Chemical Shift Separation with Controlled Aliasing for Hyperpolarized 13C Metabolic Imaging. Magn Reson Med. 2015; 74(4): 978-89. PMCID: PMC4390401


Koelsch BL, Reed GD, Keshari KR, Chaumeil MM, Bok R, Ronen SM, Vigneron DB, Kurhanewicz J, Larson PE. Rapid in vivo apparent diffusion coefficient mapping of hyperpolarized 13C metabolites. Magn Reson Med. 2015; 74(3): 622-33. PMCID: PMC4362805


Tang S, Jiang W, Chen HY, Bok R, Vigneron DB, Larson PE. A 2DRF pulse sequence for bolus tracking in hyperpolarized 13C imaging. Magn Reson Med. 2015; 74(2): 506-12. PMCID: PMC4336852


2015 Publications (70 and above) 
Keshari K, Wilson D, Sai Victor, Bok R; Jen KY, Larson P, Van Criekinge M, Kurhanewicz J, Wang ZJ. Non-invasive in vivo imaging of diabetes-induced renal oxidative stress and response to therapy using hyperpolarized 13C dehydroascorbate magnetic resonance. Diabetes. 2015; 64(2): 344-52. PMCID: PMC4303960

69 Pang Y, Wu B, Jiang X, Vigneron DB, Zhang X. Tilted microstrip phased arrays with improved electromagnetic decoupling for ultrahigh-field magnetic resonance imaging. Medicine (Baltimore). 2014; 93(28): e311. PMCID: PMC4603100
68 Sriram R, Kurhanewicz J, Vigneron D. Hyperpolarized Carbon-13 MRI and MRS Studies. in Encyclopedia of Magnetic Resonance, eds J. Griffiths and P. Bottomley, John Wiley: Chichester. eMagRes. 3: 1-14, 2014. DOI: 10.1002/9780470034590.emrstm1253
67 Wilson DM, Kurhanewicz J. Hyperpolarized 13C MR for Molecular Imaging of Prostate Cancer. J Nucl Med. 2014; 55(10): 1567-72. PMCID: PMC4349324
66 Chen L, Shu Y, Liang X, Chen EC, Yee SW, Zur AA, Li S, Xu L, Keshari KR, Lin MJ, Chien HC, Zhang Y, Morrissey KM, Liu J, Ostrem J, Younger NS, Kurhanewicz J, Shokat KM, Ashrafi K, Giacomini KM. OCT1 is a high-capacity thiamine transporter that regulates hepatic steatosis and is a target of metformin. Proc Natl Acad Sci USA. 2014; 111(27): 9983-8. PMCID: PMC4103324


Park I, Mukherjee J, Ito M, Chaumeil MM, Jalbert LE, Gaensler K, Ronen SM, Nelson SJ, Pieper RO. Changes in pyruvate metabolism detected by magnetic resonance imaging are linked to DNA damage and serve as a sensor of temozolomide response in glioblastoma cells. Cancer Res. 2014; 74(23): 7115-24. PMCID: PMC4253720


Xie H, Hanai J, Ren JG, Kats L, Burgess K, Bhargava P, Signoretti S, Billiard J, Duffy KJ, Grant A, Wang X, Lorkiewicz PK, Schatzman S, Bousamra M, Lane AN, Higashi RM, Fan TW, Pandolfi PP, Sukhatme VP, Seth P. Targeting lactate dehydrogenase-A (LDH-A) inhibits tumorigenesis and tumor progression in mouse models of lung cancer and impacts tumor initiating cells. Cell Metabolism. 2014; 19(5): 795-809. PMCID: PMC4096909


von Morze C, Carvajal L, Reed GD, Swisher CL, Tropp J, Vigneron DB. Directly detected 55Mn MRI: Application to phantoms for human hyperpolarized 13C MRI development. Magn Reson Imaging. 2014; 32(10): 1165-70. PMCID: PMC4254142


Shin PJ, Larson PE, Ohliger MA, Elad M, Pauly JM, Vigneron DB, Lustig M. Calibrationless parallel imaging reconstruction based on structured low-rank matrix completion. Magn Reson Med. 2014; 72(4): 959-70. PMCID: PMC4025999


Keshari KR, Wilson DM. Chemistry and biochemistry of 13C hyperpolarized magnetic resonance using dynamic nuclear polarization. Chem Soc Rev. 2014; 43(5): 1627-59. PMCID: PMC4086923


Bahrami N, Swisher CL, von Morze C, Vigneron DB, Larson PE. Kinetic and perfustion modeling of hyperpolarized 13C pyruvate and urea in cancer with arbitrary RF flip angles. Quant Imaging Med Surg. 2014; 4(1): 24-32. PMCID: PMC3947982


Chaumeil MM, Larson PE, Woods SM, Cai L, Eriksson P, Robinson AE, Lupo JM, Vigneron DB, Nelson SJ, Pieper RO, Phillips JJ, Ronen SM. Hyperpolarized [1-13C] glutamate: a metabolic imaging biomarker of IDH1 mutational status in glioma. Cancer Res. 2014; 74(16): 4247-57. PMCID: PMC4134724


Pang Y, Jiang X, Zhang X. Sparse Parallel Transmission on Randomly Perturbed Spiral K-space Trajectory. Quant Imaging Med Surg. 2014; 4(2): 106-111. PMCID: PMC4014875


Pang Y, Yu B, Zhang X. Enhancement of the Low Resolution Imaging Quality using Randomly Sampled Data for Multi-Slice MR Imaging. Quant Imaging Med Surg. 2014; 4(2): 136-144. PMCID: PMC4014877


Aggarwal R, Kurhanewicz J. Prostate cancer in 2013: The changing role of imaging in clinical care. Nature Reviews Urology. 2014; 11: 75-77. PMCID: PMC4057014


Pang Y, Wong E, Yu B, Zhang X. Design and Numerical Evaluation of A Volume Coil Array for Parallel MR Imaging at Ultrahigh Fields. Quant Imaging Med Surg. 2014; 4(1): 50-56. PMICD: PMC3947986


Pang Y, Yu B, Vigneron D, Zhang X. Quadrature Transmit Array Design Using Single-Feed Circularly Polarized Patch Antenna for Parallel Transmission in MR Imaging. Quant Imaging Med Surg. 2014; 4(1): 11-18. PMCID: PMC3947984


Reed G, von Morze C, Bok R, Koelsch B, Van Criekinge M, Smith K, Shang H, Larson P, Kurhanewicz J, Vigneron D. High Resolution C-13 MRI With Hyperpolarized Urea: in vivo T(2) Mapping and N-15 Labeling Effects. IEEE Trans Med Imaging. 2014; 33(2): 362-71. PMCID: PMC4011557


Park I, Larson PEZ, Tropp JL, Carvajal L, Reed G, Bok R, Robb F, Bringas J, Kells A, Pivirotto P, Bankiewicz K, Vigneron DB, Nelson SJ. Dynamic Hyperpolarized Carbon-13 Metabolic MR Imaging of Non-Human Primate Brain. Magn Reson Med. 2014; 71(1): 19-25. PMCID: PMC4041734


Swisher CL, Larson PE, Kruttwig K, Kerr AB, Hu S, Bok RA, Goga A, Pauly JM, Nelson SJ, Kurhanewicz J, Vigneron DB. Quantitative measurement of cancer metabolism using stimulated echo hyperpolarized carbon-13 MRS. Magn Reson Med. 2014; 71(1): 1-11. PMCID: PMC3659200


2014 Publications (50 and above) 
von Morze C, Bok RA, Reed GD, Ardenkjaer-Larsen JH, Kurhanewicz J, Vigneron DB. Simultaneous multiagent hyperpolarized 13C perfusion imaging. Magn Reson Med. 2014; 72(6): 1599-609. PMCID: PMC4077988


Nelson SJ, Kurhanewicz J, Vigneron DB, Larson PE, Harzstark AL, Ferrone M, van Criekinge M, Chang JW, Bok R, Park I, Reed G, Carvajal L, Small EJ, Munster P, Weinberg VK, Ardenkjaer-Larsen JH, Chen AP, Hurd RE, Odegardstuen LI, Robb FJ, Tropp J, Murray JA. Metabolic Imaging of Patients with Prostate Cancer Using Hyperpolarized [1-13C]Pyruvate. Sci Transl Med. 2013; 5(198): 198ra108. PMCID: PMC4201045. Note: This clinical trial research was not funded by the center, but benefitted from its equipment and infrastructure.


Finsterbusch J, Busch MG, Larson PE. Signal scaling improves the signal-to-noise ratio of measurements with segmented 2D-selective radiofrequency excitations. Magn Reson Med. 2013; 70(6): 1491-9. PMCID: PMC4987130


Chaumeil MM, Larson PE, Yoshihara HA, Danforth OM, Vigneron DB, Nelson SJ, Pieper RO, Phillips JJ, Ronen SM. Non-invasive in vivo assessment of IDH1 mutational status in glioma. Nat Commun. 2013; 4: 2429. PMCID: PMC3908661


Li Y, Yu B, Pang Y, Vigneron D, Zhang X. Planar quadrature RF transceiver design using common-mode differential-mode (CMDM) transmission line method for 7T MR Imaging. PLoS One. 2013; 8(11): e80428. PMCID: PMC3827179


Xing Y, Reed GD, Pauly JM, Kerr AB, Larson PE. Optimal variable flip angle schemes for dynamic acquisition of exchanging hyperpolarized substrates. J Magn Reson. 2013; 234: 75-81. PMCID: PMC3765634


Li Y, Wang C, Yu B, Vigneron D, Chen W, Zhang X. Image homogenization using pre-emphasis method for high field MRI. Quant Imaging Med Surg. 2013; 3(4): 217-223. PMCID: PMC3759133


Crane JC, Olson MP, Nelson SJ. SIVIC: Open-Source, Standards-Based Software for DICOM MR Spectroscopy Workflows. International Journal of Biomedical Imaging. 2013; 2013:169526. PMCID: PMC3732592


Keshari KR, Sriram R, Van Criekinge M, Wilson DM, Wang ZJ, Vigneron DB, Peehl DM, Kurhanewicz J. Metabolic reprogramming and validation of hyperpolarized 13C lactate as a prostate cancer biomarker using a human prostate tissue slice culture bioreactor. Prostate. 2013; 73(11): 1171-81. PMCID: PMC3976546


Keshari KR, Sai V, Wang ZJ, Vanbrocklin HF, Kurhanewicz J, Wilson DM. Hyperpolarized [1-13C]dehydroascorbate MR spectroscopy in a murine model of prostate cancer: comparison with 18F-FDG PET. J Nucl Med. 2013; 54(6): 922-8. PMCID: PMC3682497


Nelson SJ, Ozhinsky E, Li Y, Park I, Crane J. Strategies for Rapid in vivo 1H and hyperpolarized 13C MR Spectroscopic Imaging. Journal of Magnetic Resonance. 2013; 229: 187-97. PMCID: PMC3808990


Koelsch BL, Keshari KR, Peeters TH, Larson PE, Wilson DM, Kurhanewicz J. Diffusion MR of hyperpolarized 13C molecules in solution. Analyst. 2013; 138(4): 1011-4. PMCID: PMC3568999


Keshari KR, Sriram R, Koelsch BL, Van Criekinge M, Wilson DM, Kurhanewicz J, Wang ZJ. Hyperpolarized 13C-Pyruvate Magnetic Resonance Reveals Rapid Lactate Export in Metastatic Renal Cell Carcinomas. Cancer Res. 2013; 73(2): 529-38. PMCID: PMC3548990


Ohliger MA, Larson PE, Bok RA, Shin P, Hu S, Tropp J, Robb F, Carvajal L, Nelson SJ, Kurhanewicz J, Vigneron DB. Combined parallel and partial fourier MR reconstruction for accelerated 8-channel hyperpolarized carbon-13 in vivo magnetic resonance spectroscopic imaging (MRSI). J Magn Reson Imaging. 2013; 38(3): 701-13. PMCID: PMC3759833


Lodi A, Woods SM, Ronen SM. Treatment with the MEK inhibitor U0126 induces decreased hyperpolarized pyruvate to lactate conversion in breast, but not prostate, cancer cells. NMR Biomed. 2013; 26(3): 299-306. PMCID: PMC3529990


Larson PEZ, Hurd RE, Kerr AB, Pauly JM, Bok RA, Kurhanewicz J, Vigneron DB. Perfusion and diffusion sensitive 13C stimulated-echo MRSI for metabolic imaging of cancer. Magn Reson Imaging. 2013; 31(5): 635-42. PMCID: PMC3626756


Hu S, Larson PE, Van Criekinge M, Leach AM, Park I, Leon C, Zhou J, Shin PJ, Reed G, Keselman P, von Morze C, Yoshihara H, Bok RA, Nelson SJ, Kurhanewicz J, Vigneron DB. Rapid sequential injections of hyperpolarized [1-(13)C]pyruvate in vivo using a sub-kelvin, multi-sample DNP polarizer. Magn Reson Imaging. 2013; 31(4): 490-6. PMCID: PMC3625683


Pang Y, Zhang X. Interpolated compressed sensing for 2D multiple slice fast MR imaging. PLoS One. 2013; 8(2): e56098. PMCID: PMC3568040


2013 Publications (32 and above) 
Park I, Hu S, Ozawa T, Ito M, Mukherjee J, Phillips JJ, James CD, Pieper RO, Ronen SM, Vigneron DB, Nelson SJ. Evaluation of heterogeneous metabolic profile in an orthotopic human glioblastoma xenograft model using compressed sensing hyperpolarized 3D 13C magnetic resonance spectroscopic imaging. Magn Reson Med. 2013; 70(1):33-9. PMCID: PMC3630274


Pang Y, Yu B, Zhang X. Hepatic fat assessment using advanced Magnetic Resonance Imaging. Quant Imaging Med Surg. 2012; 2(3): 213-8. PMCID: PMC3496514


Keshari KR, Kurhanewicz J, Macdonald JM, Wilson DM. Generating contrast in hyperpolarized 13C MRI using ligand-receptor interactions. Analyst. 2012; 137(15): 3427-9. PMCID: PMC3600417


Larson PE, Kerr AB, Leon Swisher C, Pauly JM, Vigneron DB. A rapid method for direct detection of metabolic conversion and magnetization exchange with application to hyperpolarized substrates. J Magn Reson. 2012; 225: 71-80. PMCID: PMC3531583


von Morze C, Sukumar S, Reed GD, Larson PE, Bok RA, Kurhanewicz J, Vigneron DB. Frequency-specific SSFP for hyperpolarized 13C metabolic imaging at 14.1 T. Magn Reson Imaging. 2012; 31(2): 163-70. PMCID: PMC3651030


Wu B, Li Y, Wang C, Vigneron DB, Zhang X. Multi-reception strategy with improved SNR for multichannel MR imaging. PLoS One. 2012; 7(8):e42237. PMCID: PMC3411773


Venkatesh HS, Chaumeil MM, Ward CS, Haas-Kogan DA, James CD, Ronen SM. Reduced phosphocholine and hyperpolarized lactate provide magnetic resonance biomarkers of PI3K/Akt/mTOR inhibition in glioblastoma. Neuro Oncol. 2012; 14(3): 315-25. PMCID: PMC3280799


Chaumeil MM, Ozawa T, Park I, Scott K, James CD, Nelson SJ, Ronen SM. Hyperpolarized 13C MR spectroscopic imaging can be used to monitor Everolimus treatment in vivo in an orthotopic rodent model of glioblastoma. Neuroimage. 2012; 59(1): 193-201. PMCID: PMC3196046


Hu S, Yoshihara HA, Bok R, Zhou J, Zhu M, Kurhanewicz J, Vigneron DB. Use of hyperpolarized [1-(13)C] pyruvate and [2-(13)C]pyruvate to probe the effects of the anticancer agent dichloroacetate on mitochondrial metabolism in vivo in the normal rat. Magn Reson Imaging. 2012; 30(10): 1367-72. PMCID: PMC3480972


von Morze C, Bok RA, Sands JM, Kurhanewicz J, Vigneron DB. Monitoring urea transport in rat kidney in vivo using hyperpolarized 13C magnetic resonance imaging. Am J Physiol Renal Physiol. 2012; 302(12): F1658-62. PMCID: PMC3378100


Reed GD, Larson PE, von Morze C, Bok R, Lustig M, Kerr AB, Pauly JM, Kurhanewicz J, Vigneron DB. A Method for Simultaneous Echo Planar Imaging of Hyperpolarized 13C Pyruvate and 13C Lactate. J Magn Reson. 2012; 217: 41-7. PMCID: PMC3326401


Wu B, Zhang X, Wang C, Li Y, Pang Y, Lu J, Xu D, Majumdar S, Nelson SJ, Vigneron DB. Flexible transceiver array for ultrahigh field human MR imaging. Magn Reson Med. 2012; 68(4): 1332-8. PMCID: PMC3350759


von Morze C, Larson PEZ, Hu S, Yoshihara HAI, Bok RA, Goga A, Ardenkjaer-Larsen JH, Vigneron DB. Investigating tumor perfusion and metabolism using multiple hyperpolarized 13C compounds: HP001, pyruvate and urea. Magnetic Resonance Imaging. 2012; 30(3): 305-11. PMCID: PMC3393100


Wang C, Li Y, Wu B, Xu D, Nelson SJ, Vigneron DB, Zhang X. A practical multinuclear transceiver volume coil for in vivo MRI/MRS at 7T. Magn Reson Imaging. 2012; 30(1): 78-84. PMCID: PMC3277811


Wu B, Wang C, Lu J, Pang Y, Nelson SJ, Vigneron DB, Zhang X. Multi-channel microstrip transceiver arrays using harmonics for high field MR imaging in humans. IEEE Trans Med Imaging. 2012; 31(2): 183-91. PMCID: PMC3277810


Pang Y, Xie Z, Xu D, Kelley DA, Nelson SJ, Vigneron DB, Zhang X. A dual-tuned quadrature volume coil with mixed λ/2 and λ/4 microstrip resonators for multinuclear MRSI at 7T. Magn Reson Imaging. 2012; 30(2): 290-8. PMCID: PMC3254778


2012 Publications (16 and above) 
Larson PE, Kerr AB, Reed GD, Hurd RE, Kurhanewicz J, Pauly JM, Vigneron DB. Generating Super Stimulated-Echoes in MRI and Their Application to Hyperpolarized C-13 Diffusion Metabolic Imaging. IEEE Trans Med Imaging. 2012; 31(2): 265-75. PMCID: PMC3274664

15 Larson PEZ, Gold GE.  Science to practice: Can inflammatory arthritis be monitored by using MR imaging with injected hyperpolarized 13C-pyruvate?  Radiology. 2011; 259(2): 309-10. PMCID: PMC6939944


Chen AP, Hurd RE, Gu YP, Wilson DM, Cunningham CH. 13C MR reporter probe system using dynamic nuclear polarization. NMR Biomed. 2011; 24(5): 514-20. PMID: 21674653


Pang Y, Zhang X, Xie Z, Wang C, Vigneron DB. Common-mode differential-mode (CMDM) method for double-nuclear MR signal excitation and reception at ultrahigh fields. IEEE Trans Med Imaging. 2011; 30(11): 1965-73. PMCID: PMC3277813


von Morze C, Reed G, Shin P, Larson PE, Hu S, Bok R, Vigneron DB. Multi-band frequency encoding method for metabolic imaging with hyperpolarized [1-(13)C]pyruvate. J Magn Reson. 2011; 211(2): 109-13. PMCID: PMC3143308


Park I, Bok R, Ozawa T, Phillips JJ, James CD, Vigneron DB, Ronen SM, Nelson SJ. Detection of early response to temozolomide treatment in brain tumors using hyperpolarized 13C MR metabolic imaging. J Magn Reson Imaging. 2011; 33(6): 1284-90. PMCID: PMC4983457


Lippert AR, Keshari KR, Kurhanewicz J, Chang CJ. A hydrogen peroxide-responsive hyperpolarized 13C MRI contrast agent. J Am Chem Soc. 2011; 133(11): 3776-9. PMCID: PMC3060273


Larson PE, Hu S, Lustig M, Kerr AB, Nelson SJ, Kurhanewicz J, Pauly JM, Vigneron DB. Fast dynamic 3D MR spectroscopic imaging with compressed sensing and multiband excitation pulses for hyperpolarized 13C studies. Magn Reson Med. 2011; 65(3): 610-619. PMCID: PMC3021589


Pang Y, Zhang X. Precompensation for mutual coupling between array elements in parallel excitation. Quant Imaging Med Surg. 2011; 1(1): 4-10. PMCID: PMC3496487


Tropp J, Lupo JM, Chen AP, Calderon P, McCune D, Grafendorfer T, Ozturk-Isik E, Larson PE, Hu S, Yen YF, Robb F, Bok R, Schulte R, Xu D, Hurd R, Vigneron D, Nelson S. Multi-Channel Metabolic Imaging, with SENSE reconstruction, of Hyperpolarized [1-13C] Pyruvate in a Live Rat at 3.0 tesla on a Clinical MR Scanner. Journal of Magnetic Resonance. 2011; 208(1): 171-7. PMCID: PMC3387549


Kurhanewicz J, Vigneron DB, Brindle K, Chekmenev EY, Comment A, Cunningham CH, Deberardinis RJ, Green GG, Leach MO, Rajan SS, Rizi RR, Ross BD, Warren WS, & Malloy CR. Analysis of cancer metabolism by imaging hyperpolarized nuclei: prospects for translation to clinical research. Neoplasia. 2011; 13(2),81-97. PMCID: PMC3033588


von Morze C, Larson PE, Hu S, Keshari K, Wilson DM, Ardenkjaer-Larsen JH, Goga A, Bok R, Kurhanewicz J, Vigneron DB. Imaging of blood flow using hyperpolarized [13C]urea in preclinical cancer models. J Magn Reson Imaging. 2011; 33(3): 692-7. PMCID: PMC3566235


Pang Y, Wu B, Wang C, Vigneron DB, Zhang X. Numerical Analysis of Human Sample Effect on RF Penetration and Liver MR Imaging at Ultrahigh Field. Concepts Magn Reson Part B Magn Reson Eng. 2011; 39B(4): 206-216. PMCID: PMC3277816


Keshari KR, Kurhanewicz J, Bok R, Larson PE, Vigneron DB, Wilson DM. Hyperpolarized 13C dehydroascorbate as an endogenous redox sensor for in vivo metabolic imaging. Proc Natl Acad Sci USA. 2011; 108(46): 18606-11. PMCID: PMC3219134


Hu S, Zhu M, Yoshihara HAI, Wilson DM, Keshari KR, Shin P, Reed G, von Morze C, Bok R, Larson PEZ, Kurhanewicz J, Vigneron DB. In vivo measurement of normal rat intracellular pyruvate and lactate levels after injection of hyperpolarized [1-13C]alanine. Magnetic Resonance Imaging. 2011; 29(8): 1035-1040. PMCID: PMC3172390


2011 Publications (1 and above) 
Hu S, Balakrishnan A, Bok RA, Anderton B, Larson PE, Nelson SJ, Kurhanewicz J, Vigneron DB, Goga A. 13C-Pyruvate Imaging Reveals Alterations in Glycolysis that Precede c-Myc-Induced Tumor Formation and Regression. Cell Metabolism. 2011; 14(1): 131-42. PMCID: PMC3858338

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Conference Abstracts

2021 Abstracts

  1. Agarwal S, Sun J, Decavel-Bueff E, Bok RA, Delos Santos E, Van Criekinge M, Aggarwal R, Vigneron DB, Peehl D, Kurhanewicz J, Sriram R. Hyperpolarized 13C MR imaging of prostate cancer patient derived xenograft models and their response to therapy. ISMRM Virtual Annual Meeting, May 2021, P0763.
  2. Autry A, Vaziri S, LaFontaine M, Gordon JW, Chen HY, Kim Y, Villanueva-Meyer J, Chang SM, Clarke J, Xu D, Lupo JM, Larson PEZ, Vigneron DB, Li Y. Multi-parametric hyperpolarized 13C/1H imaging of human gliomas expressing diverse pathologic mutations. ISMRM Virtual Annual Meeting, May 2021, P0767.
  3. Chaumeil MM. Detecting Metabolic Abnormalities in the Diseased Brain by HP 13C. ISMRM Virtual Annual Meeting, May 2021, Member Initiated Symposium, MIS-14.
  4. Chen HY, Bok RA, Nguyen HG, Shinohara K, Westphalen AC, Wang ZJ, Ohliger MA, Carvajal L, Gordon JW, Larson PEZ, Aggarwal R, Kurhanewicz J, Vigneron DB. Improving Multiparametric MR - TRUS Guided Fusion Prostate Biopsies with Hyperpolarized 13C Pyruvate Metabolic Imaging: Technical Development. ISMRM Virtual Annual Meeting, May 2021, P0764.
  5. Chen HY, Gordon JW, Dwork N, Chung B, Riselli A, Bok R, Slater, Abraham MR, Vigneron DB, Larson PEZ. Probing Human Myocardial Krebs Cycle Metabolism and Response to Glucose Challenge using Hyperpolarized [2-13C]Pyruvate MR Spectroscopy. ISMRM Virtual Annual Meeting, May 2021, P0687.
  6. Dwork N, Gordon J, Tang S, O'Connor D, Larson PEZ. Low Rank Plus Joint Sparse Reconstruction for Hyperpolarized MRI, ISMRM Virtual Annual Meeting, May 2021, P2624.
  7. Gao X, Wang X, Tiong K, Labelle-Dumais C, Gould D, Chaumeil MM. Characterization of radiological findings in mouse models of cerebral small vessel diseases using multimodal MRI at 14.1 Tesla. ISMRM Virtual Annual Meeting, May 2021, P0830.
  8. Gordon JW, Chen HY, Lee P, Bok R, Ohliger MA, Ko A, Collisson E, Tempero M, Cinar P, Larson PEZ, Wang ZJ. Hyperpolarized 13C Metabolic Imaging of Patients with Pancreatic Ductal Adenocarcinoma. ISMRM Virtual Annual Meeting, May 2021, P0368.
  9. Graham JY, Autry AW, Kim Y, Bok RA, Li Y, Larson PEZ, Vigneron DB, Gordon JW. Kinetic Analysis of Multi-resolution Hyperpolarized 13C Human Brain MRI, ISMRM Virtual Annual Meeting. May 2021, P3586.
  10. Guglielmetti C, Li H, Le Page L, Shields LY, Rathmell JC, Nakamura K, Chaumeil MM. Hyperpolarized [1-13C]pyruvate detects brain glucose metabolism and sex-specific vulnerability in glucose transporter deficient mice. ISMRM Virtual Annual Meeting, May 2021, P0676.
  11. Guglielmetti C, Qiao K, Tiret B, Krukowski K, Nolan A, Rosi S, Chaumeil MM. Brain metabolic impairment after mild repetitive traumatic brain injury can be measured by hyperpolarized [1-13C]pyruvate and [13C]urea. ISMRM Virtual Annual Meeting, May 2021, P0043.
  12. Kim Y, Chen HY, Autry AW, Villanueva-Meyer J, Chang S, Li Y, Larson P, Brender J, Krishna M, Xu D, Vigneron DB, Gordon JW. Denoising of Hyperpolarized 13C MR Images of the Human Brain Using Patch-Based. Experimental Nuclear Magnetic Resonance Conference, March 2021, 1154.
  13. Kim Y, Chen HY, Autry AW, Villanueva-Meyer J, Chang SM, Li Y, Larson PEZ, Brender JR, Krishna MC, Vigneron DB, Gordon JW. Denoising of Hyperpolarized 13C MR Images of the Human Brain Using Patch-based Higher-order Singular Value Decomposition. ISMRM Virtual Annual Meeting, May 2021, P0439.
  14. Kim Y, Chung B, Gordon JW, Autry A, Tan CT, Suszczynski C, Chang S, Li Y, Xu D, Vigneron DB. Hyperpolarized [2-13C]Pyruvate Molecular Imaging with Whole Brain Coverage. ISMRM Virtual Annual Meeting, May 2021, P0233.
  15. Le Page LM, Ball J, Watkins L, Chaumeil MM. Investigating the microglial metabolome with high resolution 1H NMR. ISMRM Virtual Annual Meeting, May 2021, P0082.
  16. Lee PM, Chen HY, Gordon JW, Zhu Z, Larson PEZ, Dwork N, van Criekinge M, Carvajal L, Ohliger MA, Wang ZJ, Xu D, Kurhanewicz J, Bok RA, Aggarwal R, Munster PN, Vigneron DB. Specialized Computational Methods for Denoising, B1 Correction, and Kinetic Modeling in Hyperpolarized 13C MR EPSI Studies of Liver Tumors. ISMRM Virtual Annual Meeting, May 2021, P3349.
  17. Lee PM, Gordon JW, Wang ZJ, Zhu Z, Chen HY, Munster PN, Aggarwal R, Vigneron DB, Ohliger MA. Characterization of Arterial and Portal Venous Contributions to Metabolic Imaging of the Human Liver Using Hyperpolarized 13C-pyruvate MRI. ISMRM Virtual Annual Meeting, May 2021, P0319.
  18. Lee PM, Chen HY, Gordon JW, Wang ZJ, Bok R, Cheung K, Larson PEZ, von Morze C, Vigneron DB, Ohliger MA. Whole-Abdomen Metabolic Imaging in Healthy Volunteers Using Hyperpolarized 13C-Pyruvate MRI. World Molecular Imaging Society, Miami, Florida, October 2021, GA376.
  19. Lee PM, Chen HY, Gordon JW, Wang ZJ, Bok R, Cheung K, Larson PEZ, von Morze C, Vigneron DB, Ohliger MA. Whole-Abdomen Metabolic Imaging in Healthy Volunteers Using Hyperpolarized 13C-Pyruvate MRI. Radiological Society of North America, Chicago, Illinois, November 2021, GI02-AM.
  20. Liu X, Tang S, Zhu X, and Larson PEZ. Off-Resonance Correction with Self-Estimated Field Map for Hyperpolarized 13C Metabolic Imaging. ISMRM Virtual Annual Meeting, May 2021, P3582.
  21. Piraquive Agudelo J, Agarwal S, Bok R, Kurhanewicz J, Mattis A, Maher J, von Morze C, Ohliger MA. Hyperpolarized [1-13C] pyruvate MR spectroscopic imaging to detect metabolic changes in liver in a MCD rat model of fatty liver disease. ISMRM Virtual Annual Meeting, May 2021, P3590.
  22. Piraquive Agudelo J, Zhao H, Nolley R, Bok R, Brooks JD, Peehl DN, Kurhanewicz J, Sriram R. Magnetic Resonance Imaging Comparisons of Renal Cell Carcinoma Patient-derived Xenografts. ISMRM Virtual Annual Meeting, May 2021, P3584.
  23. Qin H, Tang S, Riselli A, Bok RA, Delos Santos R, van Criekinge M, Escobar E, Gordon JW, Aggarwal R, Chen R, Goddard G, Zhang CT, Chen A, Reed G, Ruscitto DM, Sriram R, Slater J, Larson PEZ, Vigneron DB, Kurhanewicz J. Clinical translation of simultaneous metabolic and perfusion imaging with hyperpolarized [1-13C]pyruvate and [13C, 15N2]urea, ISMRM Virtual Annual Meeting, May 2021, P0234.
  24. Sahin S, Tang S, Vaidya M, Larson PEZ. Fitting kinetic rate constants in metabolite-specific bSSFP hyperpolarized [1-13C]pyruvate MRI. ISMRM Virtual Annual Meeting, May 2021, P2840.
  25. Vaziri S, Autry A, Kim Y, Chen HY, Gordon JW, Lafontaine M, Graham J, Lupo J, Clarke J, Villanueva-Meyer J, Bush NAO, Chang S, Xu D, Larson PEZ, Vigneron DB, Li Y. Assessment of Higher-Order SVD Rank Reduction Denoising on Dynamic Hyperpolarized [13C]pyruvate Metabolic Imaging Data on Patients with Glioma. ISMRM Virtual Annual Meeting, May 2021, P2836.
  26. Villanueva-Meyer J. Imaging the Brain: What’s Missing? ISMRM Virtual Annual Meeting, May 2021, Member Initiated Symposium, MIS-14.


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