HP MRI Course

Description : Hyperpolarized NMR and MRI is an emerging modality that can be used to study biochemical reactions, including metabolic conversion, as well as pH, redox potential, perfusion, transport, and more.  It has promising clinical applications for cancer imaging, as well as potential for novel experiments in pre-clinical models and cells.  This modality is enabled by the development of Dissolution Dynamic Nuclear Polarization (DNP), which requires specialized equipment to prepare a hyperpolarized solution for experiments.  This course covers the mechanisms behind Dissolution DNP and experimental considerations. Attendance in this course and completion of a practical hyperpolarizer exam for HyperSense and/or SPINlab operation is required to use the Oxford Instruments HyperSense and/or GE SPINlab DNP polarizers at UCSF.

 

Introduction to Hyperpolarized MR (Dr. Renuka Sriram)
Date Recorded: June 28 2019 
Lab: Tour 
Link to Lecture Slides 
Link to Audio Recording

DNP Physics & Hardware (Dr. Jeremy Gordon)
Date Recorded: July 12 2019 
Lab: HyperSense/SPINlab Operation
Link to Lecture Slides 
Link to Audio Recording

DNP Agents (Dr. Dave Korenchan)
Date Recorded: July 19 2019 
Lab:  Sample Prep
Link to Lecture Slides 
Link to Audio Recording

MR Acquisition and RF Coils (Dr. Jeremy Gordon)
Date Recorded: July 26 2019 
Lab:  HyperSense/SPINlab Operation
Link to Lecture Slides 
Link to Audio Recording

Hyperpolarized MR Experimental Design (Dr. Renuka Sriram)
Date Recorded: Aug 02 2019 
Lab: Mock Hyperpolarized Studies
Link to Lecture Slides

Integration of Hyperpolarized MR Into Biomedical Research: Liver Disease (Dr. Michael Ohliger), Cardiac Disease (Dr. Peder Larson)
Date Recorded: Aug 09 2019 
Lab: Mock Hyperpolarized Studies
Link to Audio/Slides (Cardiac_Larson)  
Link to Audio/Slides (Liver_Ohliger)

Hyperpolarized Data Visualization and Analysis (Drs. Peder Larson & Jason Crane)
Date Recorded: Aug 16 2019 
Lab: Hands-on Data Demo
Link to Lecture Slides and Audio  (Larson)
Link to Lecture Slides and Audio Recording (Autry)
Link to Lecture Slides and Audio Recording (Chen)

Integration of Hyperpolarized MR Into Biomedical Research: Cancer (Dr. Pavithra Viswanath); Neurological (Dr. Lydia LePage)
Date Recorded: Aug 23 2019 
Link to Lecture Slides (LePage)
Link to Lecture Slides (Viswanath)