Upcoming Events

Date/Time: April 13-14th, 2023
Description:  The April 2023 Hyperpolarized Carbon-13 MRI Technology Development Workshop includes academic & vendor lectures, hands-on training and discussions on dissolution DNP methodology, polarizer instrumentation, MR Sequence and Acquisitions, Pre-clinical HP Chemistry Preps, Human HP Investigational Dose Formulation & Production, Clinical Translation Methods, Clinical Trial Support, and Analysis & Display Software.

2023 Workshop - Recordings & AGENDA 

Date/Time: March 17th & 18th, 2022 
Description:  The March 2022 Hyperpolarized Carbon-13 MRI Technology Development Workshop includes lectures, hands-on training and discussions on dissolution DNP methodology, polarizer instrumentation, MR Sequence and Acquisitions, Pre-clinical HP Chemistry Preps, Human HP Investigational Dose Formulation & Production, Clinical Translation Methods, Clinical Trial Support, and Analysis & Display Software.Recordings of the workshop can be found in the link below:

2022 Workshop - Recordings & AGENDA 

Date/Time: March 5th & 6th, 2020 
Description:  The March 2020 Hyperpolarized Carbon-13 MRI Technology Development Workshop includes lectures, hands-on training and discussions on dissolution DNP methodology, polarizer instrumentation, MR Sequence and Acquisitions, Chemistry & Production Preps, Clinical Translation, and Analysis & Display Software.  Registration is now closed.  Recordings of the workshop can be found in the link below:

2020 Workshop - Recordings & Brochures 

Date/Time: Thursday, March 23 - Friday, March 24, 2017
Master of Ceremonies: Dr. Dan Vigneron
Description: The March 2017 Hyperpolarized Carbon-13 MRI Technology Development Workshop includes hands-on training, lectures, and discussions on dissolution DNP methodology, polarizer instrumentation, MR Sequence and Acquisitions, Bioreactors, Animal Preps, Chemistry & sterile Pharmacy Preps, Clinical Translation, and Software.
Downloadable Content: 

2017 Brochure

On-line Workshop Presentations (Morning Sessions)
On-line Workshop Presentations (Evening Sessions)

Date/Time: Tuesday, March 29 - Wednesday, March 30, 2016
Description: The March 2016 Hyperpolarized Carbon-13 MRI Technology Development Workshop includes hands-on training, lectures, and discussions on dissolution DNP methodology, polarizer instrumentation, MR Sequence and Acquisitions, Bioreactors, Animal Preps, Chemistry & sterile Pharmacy Preps, Clinical Translation, and Software.
Downloadable Content: 

2016 Brochure

On-line Workshop Presentations (Morning Sessions)
On-line Workshop Presentations (Evening Sessions)

Date/Time: Wednesday, August 26, 2015,11:00am-4:00pm
Description: The Hyperpolarized Carbon-13 MRI Technology Development Workshop on Hyperpolarized Probes includes presentations that focus on new probe developments and also two 30 minute panel discussions associated with the pre-clinical and clinical needs of the collaborative projects for new probes.
Downloadable Content: 

2015 Brochure

Date/Time: Tuesday, March 11 & 12th, 2014, 8:00am-8:00pm
Description: 2014 HMTRC Workshop The March 2014 Hyperpolarized Carbon-13 MRI Technology Development Workshop includes lectures, hands-on training and discussions on dissolution DNP methodology, polarizer instrumentation, MR Sequence and Acquisitions, Bioreactors, Animal Preps, Chemistry Preps and Software. 
Downloadable Content: 

2014 Brochure

On-line Workshop Presentations 

Date/Time: Friday, January 10, 2014, 9:30am
Description: Coil Day at UC Berkeley
Location: Cory 140, the newest instructional lab (donated by TI and Agilent)

Date/Time: Tuesday, November 19, 2013, 8:30am-3:30pm
Description: 2013 HMTRC Retreat The UCSF Hyperpolarized MRI Technology Resource Center (HMTRC) will be holding a center retreat focused on the recent and future technological developments of the center. The retreat will include presentations from each of the Technology Research and Development (TR&D) projects on technical development updates and future directions followed by a poster session during lunch and each of the poster presenters are invited to present a summary of their poster. 
Location: Presidio, Golden Gate Club, Hawthorn Room (135 Fisher Loop, San Francisco, CA 94129)  

Date/Time: Tuesday, March 20, 2012, 8:00am-8:00pm
Description: 2013 HMTRC Workshop The March 2012 Hyperpolarized Carbon-13 MRI Technology Development Workshop includes lectures, hands-on training and discussions on dissolution DNP methodology, polarizer instrumentation, MR Sequence and Acquisitions, Bioreactors, Animal Preps, Chemistry Preps and Software. 
Location: Mission Bay, Genentech Hall Auditorium (600 16th Street, San Francisco, CA 94158)


2012 Brochure

2023 Seminars

Date/Time: Tuesday November 21st, 2023
Title: HMTRC Radiology & Biomedical Imaging Hosted Seminar 
Details: Virtual Meeting, Hosted by: Dr. Dan Vigneron, HMTRC Director, UCSF

Presentations on November 21st, 2023 included "Converging new HP Methods, Large Animal Models and Biomarkers relevant for Clinical MR" by Mathilde Hauge Lerche, PhD, Associate Professor from the Department of Health Technology Magnetic Resonance Technical University of Denmark and "Clinical HP ¹³C MR Molecular Imaging of Brain Metabolism: Probes beyond [1-¹³C]Pyruvate" by Yaewon Kim, PhD, Postdoctoral Scholar Vigneron Group from the UCSF Department of Radiology & Biomedical Imaging. 

Date/Time: Tuesday October 24th, 2023
Title: HMTRC Radiology & Biomedical Imaging Hosted Seminar 
Details: Virtual Meeting, Hosted by: Dr. Renuka Sriram, PhD, Assistant Professor, TR&D2 Lead, UCSF

Presentations on October 24th 2023 included "Interrogating Glioma Biology using Hyperpolarized ¹³C MR Imaging" by Pavithra Viswanath, PhD, Associate Professor from the UCSF Department of Radiology & Biomedical Imaging and "Preclinical HP C-13 MRI: Looking Back and Looking Forward" by Donna Peehl, PhD
Professor from the UCSF Department of Radiology & Biomedical Imaging. 

Date/Time: October 3rd - 5th, 2023
Title: Advances in Artificial Intelligence and Novel Imaging Methods Conference
Details: Hybrid In-Person & Virtual Meeting, Hosted by: the HMTRC, Center for Intelligent Imaging, UCSF Radiology and Biomedical Imaging & Christian-Albrechts-Universität

Details: The Center for Intelligent Imaging (ci2) hosted on October 3 - 5, 2023 an international conference convening researchers from UCSF Radiology and Biomedical Imaging; Christian-Albrechts-Universität, Kiel, Germany (CAU); and UCSF's Hyperpolarized MRI Technology Resource Center (HMTRC).  
 
Participants explored the latest advances in artificial intelligence and novel imaging methods. Highlights of the conference the HMTRC speakers listed below:

1. Dr. Daniel Vigneron, PhD, HP Center Director, Professor of Radiology & Biomedical Imaging, Bioengineering & Therapeutic Sciences, Neurosurgery, UCSF who presented on "HP MRI Technology Resource Center at UCSF for Technology Dissemination and Collaborations" 
2. Dr. Zhen Jane Wang, MD, Medical Director, Professor of Radiology & Biomedical Imaging, Abdominal Radiologist, UCSF who presented on "Hyperpolarized C-13 MRI Clinical Translation Update"
3. Dr. Michael Ohliger, MD, PhD, Associate Professor, Abdominal & Liver Radiologist, UCSF who presented on "Integrating C-13 in Prostate and Liver Studies"
4. Dr. Renuka Sriram, PhD, Assistant Professor, UCSF who presented on "Pre-Clinical HP C-13 at UCSF"

Date/Time: Thursday September 28th, 2023
Title: HMTRC Radiology & Biomedical Imaging Hosted Seminar 
Details: Virtual Meeting, Hosted by: Dr. Dan Vignernon, HMTRC Director, UCSF

Presentations on September 28th 2023 included "Imaging Metabolic Alterations in Neurological Disorders" by Caroline Guglielmetti, PhD, Assistant Professor from Washington University in St. Louis, Mallinckrodt Institute of Radiology and "Multi-Resolution HP [1-¹³C]Pyruvate MRI for Brain Metabolism & Perfusion" by Jasmine Hu, PhD, Postdoctoral Scholar in the Vigneron Group from the UCSF Department of Radiology & Biomedical Imaging. 

Date/Time: Tuesday July 11th, 2023
Title: HMTRC Radiology & Biomedical Imaging Hosted Seminar 
Details: Virtual Meeting, Hosted by: Dr. John Kurhanewicz PhD, Professor, UCSF

The presentation on July 11th 2023 was titled "Development of Advanced ¹³C and ¹⁵N Molecular Probes for Hyperpolarized MRI Studies" by Shinsuke Sando, PhD, Professor from the Department of Chemistry & Biotechnology, University of Tokyo. 

Date/Time: Thursday December 1st, 2022
Title: HMTRC Radiology & Biomedical Imaging Hosted Seminar 
Details: Virtual Meeting, Hosted by: Dr. Jeremy Gordon, PhD, Assistant Professor, UCSF

Presentations on December 1st, 2022 included "Dynamic Hyperpolarized ¹³C MRI of Pyruvate Metabolism in Patients with Glioma" by Yan Li, PhD, Assistant Professor from the University of California San Francisco Department of Radiology & Biomedical Imaging and "Our Initial Experience with SpinAligner" by Yi-Fen Yen, PhD, Assistant Professor from Harvard Medical School &  Massachusetts General Hospital Department of Radiology. 

*Dr Yi-Fen Yen's recording coming soon - to be posted with publication*

Date/Time: Tuesday September 27th, 2022
Title: HMTRC Radiology & Biomedical Imaging Hosted Seminar 
Details: Virtual Meeting, Hosted by: Dr. Robert Bok, MD, PhD, Professor, Director of Preclinical-Clinical Translation

Presentations on September 27th, 2022 included "Improving Multiparametric MR-Transrectal Ultrasound Guided Fusion Prostate Biopsies with HP ¹³C Pyruvate Metabolic Imaging: A technical development study" by Hsin-Yu Chen, PhD, Senior Bioengineer from the University of California San Francisco Department of Radiology & Biomedical Imaging and "Multiparametric Magnetic Resonance Imaging & Metabolic Characterization of Patient-derived Xenograft Models of Clear Cell Renal Cell Carcinoma" by Renuka Sriram, PhD, Assistant Professor, TR&D2, HMTRC Executive Member from the University of California San Francisco Department of Radiology & Biomedical Imaging. 

*Dr. Sriram's presentation coming soon - to be posted with publication*

Date/Time: Tuesday August 16th, 2022
Title: HMTRC Radiology & Biomedical Imaging Hosted Seminar 
Details: Virtual Meeting, Hosted by: Dr. Dan Vignernon, HMTRC Director, UCSF

Presentations on August 16th, 2022 included "Clinical Translation of Hyperpolarized Carbon-13 Imaging in Patients with Glioma" by Adam Autry, PhD
Research Specialist from the University of California San Francisco Department of Radiology & Biomedical Imaging and "Hyperpolarised ¹³C-MRI for Targeting Glycolytic Tumour Core in Prostate Cancer" by Nikita Sushentsev, MD, PhD Student and Gates Scholar from University of Cambridge School of Clinical Medicine
Department of Radiology.

Date/Time: Wednesday June 22nd, 2022
Title: HMTRC Radiology & Biomedical Imaging Hosted Seminar 
Details: Virtual Meeting, Hosted by: Dr. Dan Vignernon, HMTRC Director, UCSF

On June 22nd, 2022 Ferdia Gallagher, MD, PhD, Professor of Translational Imaging from the University of Cambridge Department of Radiology presented on
"Imaging Metabolism and Metabolic Heterogeneity in Oncology". Click below on the image to view the recorded presentation.

Date/Time: Tuesday June 21st, 2022
Title: International HP C-13 MRI Seminar Presentations
Details: Virtual Meeting, Hosted by: Dr. Roselle Abraham, MD, Cardiologist, UCSF

Presentations on June 21st, 2022 included "Quantification of Whole-heart Hyperpolarized ¹³C-pyruvate MRI" by Dr. Peder Larson, PhD, Associate Professor from the University of California San Francisco Department of Radiology & Biomedical Imaging and "Cardiac Function Through a HP lens - Lessons & Opportunities from Probing Human Cardiac Metabolism with HP ¹³C-Labeled Substrates" by Vlad G. Zaha, MD, PhD, Associate Professor of Internal Medicine & Biomedical Engineering, Division of Cardiology & Advanced Imaging Research Center Medical Director from UT Southwestern Medical Center Cardio-Oncology Program, Harold C. Simmons Comprehensive Cancer Center. 

**We are processing the recordings and gathering presenter permissions to post the seminar recordings. Please check back soon**

Date/Time: Thursday June 2nd, 2022
Title: International HP C-13 MRI Seminar Presentations
Details: Virtual Meeting, Hosted by: Dr. Peder Larson PhD, Associate Professor, UCSF

Presentations on June 2nd, 2022 included "Creating Consensus Protocols for Hyperpolarized ¹²⁹Xe MRI" by Peter J. Niedbalski, PhD, Research Assistant Professor
from the University of Kansas Medical Center Department of Internal Medicine and "Building a Consensus in the HP C-13 Community" by Dr. Peder Larson, PhD, Associate Professor from the University of California San Francisco Department of Radiology & Biomedical Imaging.
 

Date/Time: Thursday February 17th, 2022
Title: International HP C-13 MRI Seminar Presentations
Details: Virtual Meeting, Hosted by: Dr. Michael Ohliger, MD, PhD, Associate Professor of Radiology, HP Radiologist Leadership Committee, UCSF

Presentations on February 17th, 2022 included "HP ¹³C MR Acquisition Developments: Updates from UCSF" by Dr. Jeremy Gordon, PhD, Assistant Professor, 
TR&D1 Leader, HMTRC Executive Committee Member, from the UCSF Department of Radiology & Biomedical Imaging and "Hyperpolarized ¹³C MRI of the Human Brain" by Dr. Charles Cunningham, PhD, Professor of Medical Biophysics at the University of Toronto and Senior Scientist at the Sunnybrook Research Institute.

Date/Time: Tuesday December 7th, 2021
Title: International HP C-13 MRI Seminar Presentations
Details: Virtual Meeting, Hosted by: Dr. Zhen Jane Wang, HP Center Medical Director & Professor, UCSF

Presentations on December 7th, 2021 included "Applications of HP ¹³C-MRI in Prostate Cancer - UCSF Experience" by Dr. Robert Bok, MD, PhD, Associate Professor, TR&D2 Leader, HMTRC Executive Committee Member, from the UCSF Department of Radiology & Biomedical Imaging and "Clinical Hyperpolarised ¹³C MRI in Breast Cancer" by Dr. Ramona Woitek, PhD, Senior Research Associate and Honorary Consultant Radiologist, University of Cambridge Department of Radiology.

Date/Time: Tuesday, September 28th, 2021
Title: International HP C-13 MRI Seminar Presentations
Details: Virtual Meeting, Hosted by: Dr. Andrew Riselli, PharmD, RPh, HP Research Pharmacist, UCSF

Presentations on September 28th, 2021 included "Considerations for Translation of Hyperpolarized [1-¹³C]pyruvate to Clinical Use" by Dr. Christoffer Laustsen, PhD,
Professor and Research Director at The MR Research Centre at Aarhus University Department of Clinical Medicine and "Assessing Response to Therapy in Patients with Anaplastic Thyroid Cancer" by Dr. James Bankson, PhD, Professor, Department of Imaging Physics, Division of Diagnostic Imaging at the University of Texas MD Anderson Cancer Center. 

Date/Time: Thursday, July 15th, 2021
Title: International HP C-13 MRI Seminar Presentations
Details: Virtual Meeting, Hosted by: Dr. Peder Larson PhD, Associate Professor, UCSF

Presentations on July 15th 2021 included "Imaging metabolic impairment in neurological disorders using HP ¹³C" By Dr. Myriam Chaumeil, PhD Associate Professor of Physical Therapy & Rehabilitation Sciences, from University of California San Francisco, Department of Radiology & Biomedical Imaging and "Recent methodological developments in dDNP from the Ardenkjær-Larsen Lab" by Dr. Jan Henrik Ardenkjaer-Larsen, PhD, Professor, Head of section for MRI, from Technical University of Denmark Department of Health Technology MRI

Date/Time: Thursday, June 29th, 2021
Title: International HP C-13 MRI Seminar Presentations
Details: Virtual Meeting, Hosted by: Dr. Renuka Sriram PhD, Assistant Professor, UCSF

Presentations on June 29th 2021 included "Imaging of the tumor microenvironment and pH using hyperpolarized ¹³C" By Dr. Robert Flavell, MD, PhD
Associate Professor Chief, Molecular Imaging & Therapeutics from UCSF Department of Radiology & Biomedical Imaging and "Imaging treatment 
response with clinical hyperpolarized ¹³C-MRI" By Dr. Ferdia Gallagher, MD, PhD, Professor of Translational Imaging from University of Cambridge Department of Radiology

Date/Time: Thursday, April 22nd, 2021
Title: International HP C-13 MRI Seminar Presentations
Details: Virtual Meeting, Hosted by: Dr. Jeremy Gordon, PhD, Assistant Professor, UCSF

Presentations on April 22nd, 2021 included "Hyperpolarized Carbon-13 in Diffuse Liver Disease" By Dr. Michael Ohliger, MD, PhD Associate Professor, Abdominal & Liver Radiologist, HP Radiologist Leadership Committee Member from UCSF and "New Coils, Sequences, and Probes for Preclinical Hyperpolarized MRI" By Dr. Cornelius von Morze, PhD, Assistant Professor of Mallinckrodt Institute of Radiology from Washington University School of Medicine in St. Louis. 

Date/Time: Tuesday, February 23rd, 2021
Title: International HP C-13 MRI Seminar Presentations
Details: Virtual Meeting, Hosted by: Dr. Dan Vignernon, HMTRC Director, UCSF

Presentations on February 23rd, 2021 included "Hyperpolarized Carbon-13 Studies in Brain Tumors at UCSF" By Dr. Javier Villanueva-Meyer, MD
Assistant Professor of Clinical Radiology in Neuroradiology, HP Radiologist Leadership Committee from UCSF and "Hyperpolarized MRI Research at UT Southwestern" By Dr. Craig Malloy, MD, Richard A. Lange Chair in Cardiology, Professor & Medical Director of the Advanced Imaging Research Center from UT Southwestern Medical Center.

Date/Time: Thursday, January 28th, 2021
Title: International HP C-13 MRI Seminar Preclinical Presentations
Details: Virtual Meeting, Hosted by: Dr. John Kurhanewicz PhD, Professor, UCSF

Presentations on January 28th 2021 included "Hyperpolarized ¹³C Metabolic Biomarkers of Castrate Resistant and Metastatic Neuroendocrine Prostate Cancer" By Dr. Renuka Sriram PhD, Associate Researcher, UCSF and "Hyperpolarized Dihydroxyacetone is a Sensitive Detector of Hepatic Glucose Metabolism" By Dr. Matthew Merritt PhD, Associate Professor U. of Florida. 

Date/Time: Thursday, December 17th, 2020
Title: International HP C-13 MRI Seminar Series Kick-off
Details: Virtual Meeting, Hosted by: Dr. Dan Vignernon, HMTRC Director, UCSF

On November 19th, 2020 the Center hosted our International HP C-13 MRI Seminar Series Kick-off. Click to watch the presentations below:

Date/Time: Thursday, November 19th, 2020 
Title: UCSF's Mini-Symposium on Denoising
Details: Virtual Meeting, Hosted by: Dr. Jeremy Gordon & Dr. Peder Larson

On November 19th, 2020 the Center hosted a virtual mini-symposium that discussed noise reduction techniques for hyperpolarized MRI. This forum showcased several techniques in development and discussed their merit. View the agenda below. For more information about presentations or resources email [email protected].

Introductory Remarks with Dr. Jeremy Gordon, Assistant Professor & TR&D1 leader

Overview of Denoising in MRI with Dr. Nicholas Dwork, Postdoctoral Scholar

Denoising and Fitting for in-vivo Spectroscopy with Dr. Donghyun Hong, Postdoctoral Scholar 

Higher Order SVD Denoising on Patients with Glioma with Dr. Sana Vaziri, Postdoctoral Scholar

Denoising with Patch-based Higher Order Singular Value Decomposition in the Brain 
with Dr. Yaewon Kim, Postdoctoral Scholar

Tensor Signal Enhancement and Optimal Multi-channel Receiver Combination 
with Dr. Hsin-Yu Chen, Postdoctoral Scholar

Denoising, B1 Correction, and Kinetic Modeling on Patients with Liver Tumors 
with Philip Lee, Graduate Student

Discussion & Closing Remarks Moderated with Dr. Peder Larson, Associate Professor & TR&D3 leader
& with Dr. Nicholas Dwork, Postdoctoral Scholar

Bio E 297 - Hyperpolarized MRI Seminar

Dates: Summer 2019: June 28 thru August 23

Flyer:

Date/Time: Thursday, July 12, 2018, 3 p.m. - 4 p.m.
Title: Development and Translation of Hyperpolarized Carbon-13 Cancer Imaging for Therapy Response Monitoring 
Speaker: Dr. Zi Zhu, PhD
Details: Genentech Hall, N-114, Hosted by: Dr. Dan Vigneron, PhD

Date/Time: Friday, February 02, 2018, 10:00 a.m - 11:00 a.m.
Title: Diamonds On The Inside: Imaging Nanodiamonds with Hyperpolarized MRI
Speaker: David Waddington, PhD, University of Sydney, Australia
Details: Mission Bay, Byers Hall 212 Hosted by: Dr. Dan Vigneron, PhD

Link to Bio: here

Link to Abstract: here 

Date/Time: Thursday, January 25, 2018,11:30 a.m - 12:30 p.m.
Title: Cardiac Hyperpolarized Magnetic Resonance – Physiology and Pathophysiology
Speaker: Dr Michael S. Dodd DPhil, MBiochem, MRSB, Novo Nordisk Fellow, Cardiac Metabolism Research Group, University of Oxford
Details: Mission Bay, Byers Hall 215, Hosted by: Dr. Dan Vigneron, PhD

Link to Abstract: here 

Date/Time: Thursday, January 18, 2018, 11:00 a.m - 12:00 p.m.
Title: Guest Talk 
Speaker: Dr. Simone Angela Walker. Biomedical Engineer, Research Associate, Stanford University, CA
Details: Mission Bay, Byers Hall 215 Hosted by: Dr. Dan Vigneron, PhD

Date/Time: Tuesday, December 12, 2017, 3:00 p.m - 4:00 p.m.
Title: Development of High Spatiotemporal Resolution Imaging of Hyperpolarized C-13 Compounds using the Balanced Steady-State Free Precession Sequence
Speaker: Eugene Milshteyn, Graduate Student, Bioengineering
Details: Mission Bay, Byers Hall 212 

Event Flyer:  here

Date/Time: Wednesday, October 25, 2017, 11:00 a.m - 12:00 p.m.
Title: Role of Data Analysis in Precision Medicine-Metabolic Dosimetry
Speaker: Dr. James Slater RPh, PhD, Director of Education and Special Projects for Isotope Imaging
Details: This lecture is the first in a series of five to explore how major advancements in data analysis provide critical information for addressing individualized treatment planning and how data analysis translates to the clinical world. We will focus on the use of clinical and imaging data to predict pharmacokinetics and targeting of drugs. Mission Bay, Byers Hall 215 Hosted by: Dr. Dan Vigneron, PhD

Date/Time: Thursday, November 17, 2016,11:00am-12:00pm
Title: Interleaved Echo-Planar Imaging of Hyperpolarized Molecules: From Rats to Humans
Speaker: Justin Lau, PhD Candidate, University of Toronto
Details: Mission Bay, Byers Hall 212 Hosted by: Dr. Dan Vigneron, PhD

Date/Time: Monday, June 27, 2016,11:00am-12:00pm
Title: Substrate selection in the hypertrophic and failing mouse heart
Speaker: Matthew Merritt, PhD, Associate Professor, University of Florida, Department of Biochemistry and Molecular Biology
Details: Mission Bay, Byers Hall 212 

Date/Time: Tuesday, July 28, 2015,11:00am-12:00pm
Title: Increased TCA Cycle Turnover in the Failing Heart: A Role for Anaplerotic Therapy
Speaker: Matthew Merritt, PhD, Assistant Professor, University of Texas Southwestern Medical Center, Advanced Imaging Research Center, Radiology
Details: Mission Bay, Byers Hall 212

Date/Time: Summer Quarter 2015; July 9 - August 27
Title: UCSF Bioengineering 297: Hyperpolarized MR Seminar 
Description: Hyperpolarized NMR and MRI is an emerging modality that can be used to study biochemical reactions, including metabolic conversion, as well as pH, redox potential, perfusion, transport, and more.  It has promising clinical applications for cancer imaging, as well as potential for novel experiments in pre-clinical models and cells.  This modality is enabled by the development of Dissolution Dynamic Nuclear Polarization (DNP), which requires specialized equipment to prepare a hyperpolarized solution for experiments.  This course covers the mechanisms behind Dissolution DNP and experimental considerations.
Location: Mission Bay, Byers Hall 215 (Lectures); Biomedial NMR & Surbeck Laboratory (Lab)
Details: Thursday  2:00pm-3:00pm (lecture) & 3:00pm-5:00pm (lab) Hosted by: Dr. Peder Larson​

Date/Time: Thursday, April 30, 2015, 2:30pm-3:30pm
Title: Modeling and Model-Based Imaging of HP Substrates
Speaker: James A. Bankson, PhD, Associate Professor, University of Texas MD Anderson Cancer Center, Department of Imaging Physics, Division of Diagnostic Imaging
Details: Mission Bay, Byers Hall 212 

Date/Time: Winter Quarter 2015; January 19 - March 20, MW-2:00pm-3:30pm
Title: UCSF Bioengineering 241: Magnetic Resonance Spectroscopy 
Description: This course assumes a basic understanding of magnetic resonance physics and will cover in detail the topic of nuclear magnetic resonance spectroscopy including both in vitro and in vivo applications. The course will cover basic theory, underlying biochemistry and physiology, basic and advanced techniques for acquiring and processing MR spectroscopic data, and biomedical applications for this emerging medical imaging modality. The course will also have four hands-on labs that will allow students to actually acquire and analyze spectroscopy data from human tissue extracts, a 3D cell culture bioreactor and a murine model of cancer. In addition to 2 didactic lectures per week, the course will have weekly discussion sessions focused on understanding the material covered in both lectures and labs. While not a pre-requisite, taking either Bioengineering 240, Biomedical Imaging 201, or a similar course that covers the basics of magnetic resonance imaging or NMR is advised. (Lecture & Lab)
Details: Mission Bay, Byer Hall 215 (Lectures); Biomedical NMR Lab (Lab) Hosted by: Dr. John Kurhanewicz, Guest Lecturer: Dr. Peder Larson 

Date/Time: Thursday, January 15, 2015,12:15pm-1:15pm
Title: Technology Innovation at GE Healthcare
Speaker: Michael J. Harsh, Vice President and Executive Advisor GE Ventures 
Details: Mission Bay, Mission Hall 1401

Date/Time: Tuesday, November 18, 2014,11:00am-12:00pm
Title: Redox molecular imaging using in vivo DNP-MRI
Speaker: Hideo Utsumi, PhD, Professor, Research Managing Director, Innovation Center for Medical Redox Navigation, Kyushu University 
Details: Mission Bay, Byers Hall 215 

Date/Time: Friday, October 3, 2014, 10:30am-11:30am
Title: Substrate Selection in Heart Failure
Speaker: Mathew Merritt, PhD, Assistant Professor University of Texas Southwestern Medical Center Advanced Imaging Research Center, Radiology 
Details: Mission Bay, Byers Hall 212 

Date/Time: Thursday, March 6, 2014, 1:00pm-2:00pm
Title: Nonlinear Gradient Encoding: Design and Implementation on a 3T Human Scanner
Speaker: Leo Tam, PhD, Post-doctoral Fellow Yale University, Biomedical Imaging 
Details: Mission Bay, Byers Hall 212 

Date/Time: Thursday, January 23, 2014, 4:00pm-5:00pm
Title: Dynamic metabolic imaging with 3D spiral CSI for hyperpolarized [2-¹³C]pyruvate
Speaker: Sonal Josan, PhD, Senior Research Scientist Stanford University Department of Radiology 
Details: Mission Bay, Byers Hall 212

Date/Time: Thursday, January 16, 2014,12:00pm-1:00pm
Title: Hyperpolarized Carbon-13 Studies of Intermediary Metabolism: Gluconeogenesis in the Liver, Compartmentation and Substrate Competition in the Heart
Speaker: Matthew Merritt, PhD, Assistant Professor
 University of Texas Southwestern Medical Center Advanced Imaging Research Center, Radiology 
Details: Mission Bay, Byers Hall 215

Date/Time: Summer Quarter 2013; July 2 – August 13, 2013; Tuesdays – 3:00pm-3:45pm (lectures); 3:45pm-4:30pm (lab)
Title: UCSF Bioengineering 297: Hyperpolarized MR Seminar (Lectures & Lab) 
Instructors: Peder Larson, PhD; Cornelius vonMoze, PhD; David Wilson, MD, PhD; Subramaniam Sukumar, PhD, and Mark van Criekinge 
Details: Mission Bay, Byers Hall 215 (Lectures); Biomedical NMR Lab or Surbeck Lab for Advanced Imaging (Lab) 
Description: Hyperpolarized NMR and MRI is an emerging modality that can be used to study biochemical reactions, including metabolic conversion, as well as pH, redox potential, perfusion, transport, and more. It has promising clinical applications for cancer imaging, as well as potential for novel experiments in pre-clinical models and cells. This modality is enabled by the development of Dissolution Dynamic Nuclear Polarization (DNP), which requires specialized equipment to prepare a hyperpolarized solution for experiments. This course covers the mechanisms behind Dissolution DNP and experimental considerations. Attendance in this course and completion of a practical HyperSense operation Exam is required to used the Oxford Instruments HyperSense DNP polarizers at UCSF.

Date/Time: Tuesday, July 23, 2013, 10:00am-11:00am
Title: Advances in Free Radical Imaging Using Overhauser-Enhanced MRI
Speaker: Brandon Armstrong, PhD, Post-doctoral Fellow Harvard University, Department of Physics 
AA., Martinos Center for Biomedical Imaging at Massachusetts General Hospital 
Details: Mission Bay, Byers Hall 215

Date/Time: Tuesday, February 12, 2012,10:30am
Title: Regulation of Renal Urea Transport
Speaker: Dr. Jeff M. Sands, MD, Professor of Medicine and Physiology, 
Renal Division Director 
Emory University 
Details: Mission Bay, Byers Hall 212

Date/Time: Winter Quarter 2012; January 11 – March 12, MW – 2:00pm-3:30pm
Title: UCSF Bioengineering 241: Magnetic Resonance Spectroscopy
Faculty: Faculty: Drs. John Kurhanewicz, Dan Vigneron, Sarah Nelson, Sabrina Ronen, Susan Moyher Noworolski, Duan Xu, Peder Larson
Details: Mission Bay, Byers Hall 212  
Course Description: This course will cover a broad spectrum from basic MR physics to clinical applications of MR spectroscopy that provides noninvasive physiologic and biochemical information. The course will cover basic theory, underlying biochemistry and physiology, basic and advanced techniques for acquiring and processing MR spectroscopic data, and biomedical applications for this emerging medical imaging modality. Bio-engineering 240, which provides basics of conventional MR imaging, is not a pre-requisite but is advised. 

Date/Time: Monday, February 6, 2012, 3:30pm-4:30pm
Title: Visualising Cardiomyocyte Function Using Hyperpolarised Carbon-13 Magnetic Resonance
Speaker: Marie Schroeder, PhD, Sir Henry Wellcome Post-doctoral Fellow, 
Department of Physiology, Anatomy and Genetics 
University of Oxford 
Details: Mission Bay, Byers Hall 212

Date/Time: Friday, December 9, 2011, 10:00am-11:00am
Title: Oxygen Images of Tumors in Living Animals from Mice to Rabbits and Beyond
Speaker: Professor Howard Halpern, MD, PhD, Center for EPR Imaging In Vivo Physiology, 
Department of Radiation and Cellular Oncology, 
University of Chicago
 
Details: Mission Bay, Byers Hall 212

Date/Time: November 27 – December 2, 2011
Title: RSNA 2011 Presentation - Basic Principles of Hyperpolarized Carbon-13 Magnetic Resonance Imaging and Spectroscopy
Speaker: Michael Ohliger, MD, PhD 
Details: RSNA Conference; Space Number: LL-MIE2453

Date/Time: November 27 – December 2, 2011
Title: Educational Exhibit - Visualization and Analysis of Dynamic MRSI and Perfusion MRI Using the Open-Source SIVIC Software Framework
Details: RSNA Conference; Space Number: LL-INE1174 

Date/Time: Monday, July 18, 2011, 4:00pm-5:00pm
Title: High Frequency Dynamic Nuclear Polarization in Rotating Solids -- Amyloid and Membrane Proteins
Speaker: Professor Robert Griffin, PhD, Director, Francis Bitter National Magnet Laboratory, Massachusetts Institute of Technology (MIT)
 
Details: Mission Bay, Byers Hall 212

Date/Time: Monday, June 26, 2017, 3:00pm - 4:00pm
Event: Exit Seminar 
Title: Development & Translation of 3D Dynamic Hyperpolarized ¹³C MR Metabolic and Perfusion Imaging From Mice to Patients
Speaker: Dr. Hsin-Yu Chen, Bioengineering Graduate Group
Details: Mission Bay, Byers Hall 212  Hosted by: Dr. Dan Vigneron, PhD

Date/Time: Monday, December 12, 2016, 12:00pm - 1:00pm
Event: Exit Seminar
Title: Rapid & Robust Non-Cartesian Magnetic Resonance Imaging Methods
Speaker: WenWen Jiang, Graduate Student
Details: Mission Bay, Genentech Hall N-114/Winsley Room Hosted by: Drs. Peder Larson (UCSF) & Michael "Miki" Lustig (UC Berkeley)

Date/Time: Thursday, February 23, 2012; 4:30pm
Publications Featured: 1) Lau AZ, Chen AP, Hurd RE, Cunningham CH. Spectral-spatial excitation for rapid imaging of DNP compounds. NMR in Biomedicine. 2011. doi:10.1002/nbm.1743 2) Mansson S, Petersson JS, Scheffler K. Fast metabolite mapping in the pig heart after injection of hyperpolarized (13)C-pyruvate with low-flip angle balanced steady-state free precession imaging. Magnetic Resonance in Medicine. 2012. doi:10.1002/mrm.24183 3) Wiesinger F, Weidl E, Menzel MI, Janich MA, Khegai O, Glaser SJ, Haase A, et al. IDEAL spiral CSI for dynamic metabolic MRI imaging of hyperpolarized [1-(13)C]pyruvate. Magnetic Resonance in Medicine. 2011. doi.10.1002/mrm.23212 
Details: Mission Bay, Byers Hall 209

Date/Time: Thursday, January 19, 2012; 4:30pm
Publications Featured: Witney TH, Kettunen MI, Brindle KM. Kinetic Modeling of Hyperpolarized ¹³C Label Exchange between Pyruvate and Lactate in Tumor Cells. The Journal of Biological Chemistry. 2011; 286(28): 24572-24580. 
Details: Mission Bay, Byers Hall 209