Surbeck Laboratory for Advanced Imaging

The California Institute for Quantitative Biomedical Research (QB3) houses the Surbeck Laboratory for Advanced Imaging which includes a 7T GE 950 whole body scanner, a new 750 3T research scanner, microscopy, computational and other facilities. The only current clinical ¹³C Dynamic Nuclear Polarizer in the world is installed in a clean room directly adjacent to the 3T scan room to permit human investigations of this new technology. A second, commercial DNP polarizer (Oxford Instrument’s HyperSense) is sited between the 3T and 7T MR scanners to allow development and animal studies on both scanners. A GE SPINlab multisample polarizer and QC unit prototype (funded by NIH Shared Equipment grant S10RR029570) is also sited between the human MR scanners and is used currently for preclinical animal studies and is being developed for future human HP ¹³C-pyruvate studies. There is also an electronics shop, a machine shop and a server room that is dedicated to meet the heavy computational needs of the research programs in the building. There is also a three-room suite for animal management and housing. The Surbeck Laboratory also has facilities for managing human subjects including offices, a changing room, preparation room, and restroom.

UCSF Biomedical NMR Laboratory

The Biomedical NMR Lab on the Mission Bay Campus at UCSF occupies 1660 sq. ft. and currently houses a high field multi-nuclear 500 MHz HR-MAS NMR spectrometer and 600 MHz multinuclear micro-imaging spectrometer that are uniquely integrated with two Oxford Instruments DNP polarizers, one HyperSense commercial instrument funded through NIH equipment grant S10RR024587 and a “test-bed” instrument purchased through NIH P41EB013598. A large number of high- field spectrometers (400 MHz, 2 500 MHz, 2 600 MHz and a 800 MHz) with multi-nuclear capabilities and sensitive cryo-probes are also available within the UCSF NMR lab. Both magnets are dedicated to running biomedical samples with complimentary features, including high-resolution magic angle spinning (HR-MAS) spectroscopy, and micro-imaging capabilities that allow for NMR studies of biopsy and surgical tissues, cell and tissue cultures and murine models of cancer. By placing the HyperSense^TM polarizer adjacent to the two high field NMR spectrometers, we can take advantage of the unique features of each system. For more information visit the Preclinical MR Imaging and Spectroscopy Lab offered by UCSF Department of Radiology & Biomedical Imaging.

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