2023 Hyperpolarized MRI Course
Course Details
Organizers & Instructors:
Jeremy Gordon, PhD
Assistant Professor
[email protected]
Renuka Sriram, PhD
Assistant Professor
[email protected]
Additional Lecturers:
Adam Autry, PhD
Specialist
[email protected]
Myriam Chaumeil, PhD
Associate Professor
[email protected]
Hsin-Yu Chen, PhD
Senior Bioengineer
[email protected]
Xiao Ji, PhD
Specialist
[email protected]
Yaewon Kim, PhD
Postdoctoral Scholar
[email protected]
Peder Larson, PhD
Professor
[email protected]
Michael Ohliger, MD, PhD
Associate Professor, Abdominal & Liver Radiologist
[email protected]
Celine Taglang, PhD
Postdoctoral Scholar
[email protected]
Pavithra Viswanath, PhD
Associate Professor
[email protected]
Administrative Support:
Jenny Che
Program Officer
Contact for: Course Administrative Oversight
[email protected]
Jenna Bernard, PhD
Data Scientist & Communication Manager
Contact for: Course Website & Virtual Meetings
[email protected]
Cresini Tabaranza-David
Executive Analyst
Contact for In-person Room Support
[email protected]
Phone: (415) 514-4450
Course Description:
Hyperpolarized NMR and MRI is an emerging modality that can be used to study biochemical reactions, including metabolic conversion, as well as pH, redox potential, perfusion, transport, and more. It has promising clinical applications for cancer imaging, as well as potential for novel experiments in pre-clinical models and cells. This modality is enabled by the development of Dissolution Dynamic Nuclear Polarization (DNP), which requires specialized equipment to prepare a hyperpolarized solution for experiments. This course covers the mechanisms behind Dissolution DNP and experimental considerations. *The HP MRI Book titled "Hyperpolarized Carbon-13 Magnetic Resonance Imaging and Spectroscopy" Academic Press, Elsevier 2021 editor: Dr. Peder Larson is available for purchase online.
Course Materials
Lecture 1:
Air Date: June 21st 2023
Topic: Introduction and DNP Physics
Lecturers:
Renuka Sriram, PhD, Assistant Professor
& Xiao Ji, PhD, Specialist
Presentation Recording:
(52 min)
Reference Materials:
HP MRI Book - Chapter 1 DNP Physics*
HP MRI Book - Chapter 2 DNP Hardware*
Lecture 2:
Air Date: June 28th 2023
Topic: DNP Hardware - SpinAligner and Hypersense SPINlab
Lecturer:
Yaewon Kim, PhD, Postdoctoral Scholar
Presentation Recording:
(47 min)
Reference Materials:
HP MRI Book - Chapter 1 DNP Physics*
HP MRI Book - Chapter 2 DNP Hardware*
Lecture 3:
Air Date: July 12th 2023
Topic: Hyperpolarized MR Experimental Methods – Cells and Animals
Lecturer:
Renuka Sriram, PhD, Assistant Professor
Presentation Recording:
(56 min)
Reference Materials:
HP MRI Book - Chapter 4 Experimental Methods Preclinical*
Lecture 4:
Air Date: July 19th 2023
Topic: DNP Agents
Lecturer:
Celine Taglang, PhD, Postdoctoral Scholar
Presentation Recording:
(42 min)
Reference Materials:
HP MRI Book - Chapter 6 Agents and Biochemical Interactions*
Lecture 5:
Air Date: From 2021 Course (July 12th 2021)
Topic: MR Acquisition
Lecturer:
Jeremy Gordon, PhD, Assistant Professor
Presentation Recording:
From 2021 Course: (1hr 8 min)
Reference Materials:
HP MRI Book - Chapter 3 Acquisition Methods*
Review Articles:
Comparison of acquisition schemes for hyperpolarised ¹³C imaging
Hyperpolarized Metabolic MRI-Acquisition, Reconstruction, and Analysis Methods
Lecture 6:
Air Date: Aug 2nd 2023
Topic: Hyperpolarized MR Experimental Methods – Human
Lecturer:
Hsin-Yu Chen, PhD, Senior Bioengineer
Presentation Recording:
(56 min)
Reference Materials:
N/A
Lecture 7:
Air Date: Aug 9th 2023
Topic: Integration of Hyperpolarized MR Into Biomedical Research: Neurological; Cardiac Disease
Lecturers:
Peder Larson, PhD, Professor
&
Myriam Chaumeil, PhD, Associate Professor
Presentation Resources:
Applications of Hyperpolarized Carbon-13 MR: The Heart
Recording (51 min)
Integration of HP MRI Into Biomedical Research: Neurological
Slides
Reference Materials:
HP MRI Book - Chapter 9 Neurological*
HP MRI Book - Chapter 10 Cardiac*
Lecture 8:
Air Date: From 2021 Course (August 23rd, 2021)
Topic: Integration of Hyperpolarized MR Into Biomedical Research: Prostate & Liver Disease
Lecturers:
Michael Ohliger, MD, PhD, Associate Professor, Abdominal & Liver Radiologist
Presentation Recording:
2021 Recording (52 min)
Reference Materials:
HP MRI Book - Chapter 11 Liver*
Lecture 9:
Air Date: Aug 23rd 2023
Topic: Integration of Hyperpolarized MR Into Biomedical Research: Cancer
Lecturers:
Pavithra Viswanath, PhD, Associate Professor
& Adam Autry, PhD, Specialist
Presentation Recordings:
Preclinical Integration of HP MR into Biomedical Research - Cancer
(29 min)
Clinical Translation of HP C-13 Imaging for Patients with Glioma
(32 min)
Reference Materials:
HP MRI Book - Chapter 8 Cancer*
Lecture 10:
Air Date: Aug 30th 2023
Topic: Hyperpolarized Data Visualization and Analysis
Lecturer:
Peder Larson, PhD, Professor
Hands-on Training:
- Data Analysis
Presentation Recording: Storage, Visualization, and Analysis of Hyperpolarized C-13 MR Data
(84 min)
Data Analysis Hands-on
(30 min)
Reference Materials:
HP MRI Book - Chapter 7 Analysis and Visualization*
Live Demo Links:
My Binder - Demo Notebooks
My Binder - Exercises
GitHub - Exercises
Hands-on Training Resources:
Jupyter Notebook
UCSF Radiology Computational Resources
